Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

AF Abdel-Wahab, W Mahmoud, RM Al-Harizy - Pharmacological research, 2019 - Elsevier
Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

EMT factors and metabolic pathways in cancer

I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

[HTML][HTML] Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma

K Bi, MX He, Z Bakouny, A Kanodia, S Napolitano… - Cancer cell, 2021 - cell.com
Immune checkpoint blockade (ICB) results in durable disease control in a subset of patients
with advanced renal cell carcinoma (RCC), but mechanisms driving resistance are poorly …

Short overview of ROS as cell function regulators and their implications in therapy concepts

L Milkovic, A Cipak Gasparovic, M Cindric, PA Mouthuy… - Cells, 2019 - mdpi.com
The importance of reactive oxygen species (ROS) has been gradually acknowledged over
the last four decades. Initially perceived as unwanted products of detrimental oxidative …

Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours

S Missiroli, M Perrone, I Genovese, P Pinton… - EBioMedicine, 2020 - thelancet.com
Mitochondria are dynamic organelles that have essential metabolic activity and are
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …

The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics

DP Panigrahi, PP Praharaj, CS Bhol… - Seminars in cancer …, 2020 - Elsevier
Mitophagy is an evolutionarily conserved cellular process which selectively eliminates
dysfunctional mitochondria by targeting them to the autophagosome for degradation …

Gut bacteria signaling to mitochondria in intestinal inflammation and cancer

DN Jackson, AL Theiss - Gut microbes, 2020 - Taylor & Francis
The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming

J Liu, ZX Liu, QN Wu, YX Lu, CW Wong, L Miao… - Nature …, 2020 - nature.com
Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long
noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying mechanisms …

Non-canonical mechanisms regulating hypoxia-inducible factor 1 alpha in cancer

L Iommarini, AM Porcelli, G Gasparre… - Frontiers in oncology, 2017 - frontiersin.org
Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and
nutrient-deprived environment and drives progression to malignancy in human solid …

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

D Jia, M Lu, KH Jung, JH Park, L Yu… - Proceedings of the …, 2019 - National Acad Sciences
Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between
glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis …