Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy
AF Abdel-Wahab, W Mahmoud, RM Al-Harizy - Pharmacological research, 2019 - Elsevier
Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …
EMT factors and metabolic pathways in cancer
I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
[HTML][HTML] Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma
Immune checkpoint blockade (ICB) results in durable disease control in a subset of patients
with advanced renal cell carcinoma (RCC), but mechanisms driving resistance are poorly …
with advanced renal cell carcinoma (RCC), but mechanisms driving resistance are poorly …
Short overview of ROS as cell function regulators and their implications in therapy concepts
L Milkovic, A Cipak Gasparovic, M Cindric, PA Mouthuy… - Cells, 2019 - mdpi.com
The importance of reactive oxygen species (ROS) has been gradually acknowledged over
the last four decades. Initially perceived as unwanted products of detrimental oxidative …
the last four decades. Initially perceived as unwanted products of detrimental oxidative …
Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours
Mitochondria are dynamic organelles that have essential metabolic activity and are
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …
The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics
Mitophagy is an evolutionarily conserved cellular process which selectively eliminates
dysfunctional mitochondria by targeting them to the autophagosome for degradation …
dysfunctional mitochondria by targeting them to the autophagosome for degradation …
Gut bacteria signaling to mitochondria in intestinal inflammation and cancer
DN Jackson, AL Theiss - Gut microbes, 2020 - Taylor & Francis
The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …
intestine as well as in the pathophysiology of diseases including inflammatory bowel …
Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming
J Liu, ZX Liu, QN Wu, YX Lu, CW Wong, L Miao… - Nature …, 2020 - nature.com
Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long
noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying mechanisms …
noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying mechanisms …
Non-canonical mechanisms regulating hypoxia-inducible factor 1 alpha in cancer
L Iommarini, AM Porcelli, G Gasparre… - Frontiers in oncology, 2017 - frontiersin.org
Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and
nutrient-deprived environment and drives progression to malignancy in human solid …
nutrient-deprived environment and drives progression to malignancy in human solid …
Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between
glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis …
glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis …