Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Lysosomes and the endoplasmic reticulum (ER) are Ca 2+ stores mobilized by the second
messengers NAADP and IP 3, respectively. Here, we establish Ca 2+ signals between the …

Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM)
forms signaling complexes that regulate the membrane potential and contractility of vascular …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

Abnormalities in the endosomal-autophagic-lysosomal (EAL) system are an early event in
Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these …

Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

Lysosomes function not only as degradatory compartments but also as dynamic intracellular
calcium ion stores. The transient receptor potential mucolipin 1 (TRPML1) channel mediates …

The contractile state of resistance arteries and arterioles is a crucial determinant of blood
pressure and blood flow. Physiological regulation of arterial contractility requires constant …