Rosmarinic acid attenuates acrylamide induced apoptosis of BRL-3A cells by inhibiting oxidative stress and endoplasmic reticulum stress

Z Hong, W Minghua, N Bo, Y Chaoyue… - Food and Chemical …, 2021 - Elsevier
Acrylamide (AA) is a common endogenous contaminant in food, with a complex toxicity
mechanism. The study on liver damage to experimental animals caused by AA has aroused …

[PDF][PDF] The anticancer potency of artemisinin and its derivatives

Y Lin, Z Song, Z Xi - SPR, 2021 - scholar.archive.org
Artemisinin and its derivatives (Artemisinins) have long been used as antimalaria drugs with
considerable safety and efficacy. In recent preclinical research, artemisinins also exert an …

Studies on the mitochondrial, immunological and inflammatory effects of solvent fractions of Diospyros mespiliformis Hochst in Plasmodium berghei-infected mice

OM David, JO Olanlokun, BE Owoniyi, MO Ayeni… - Scientific Reports, 2021 - nature.com
The use of medicinal plants in the treatment of malaria is gaining global attention due to their
efficacy and cost effectiveness. This study evaluated the bioactivity-guided antiplasmodial …

Comparative antimalarial, toxicity and mito-protective effects of Diospyros mespiliformis Hochst. ex A. DC. and Mondia whitei (Hook. f.) Skeels on Plasmodium berghei …

JO Olanlokun, O Bodede, G Prinsloo… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Diospyros mespiliformis Hochst. ex A. DC. and
Mondia whitei (Hook. f.) Skeels are traditionally used in Africa for the treatment of malaria …

Regulated rutin co-administration reverses mitochondrial-mediated apoptosis in Plasmodium berghei-infected mice

OJ Oludele, BA Adisa, OO Olufunso - Biochemical and Biophysical …, 2020 - Elsevier
Malarial infection causes apoptosis in hepatocytes. However, it is not known if co-
administration of antimalarial drug with rutin will reverse the apoptotic effects of malarial …

[HTML][HTML] Elucidation of the Active Agents in a West African Ground Herbal Medicine Formulation That Elicit Antimalarial Activities in In Vitro and In Vivo Models

S Owumi, JO Olanlokun, B Wu, AM Duro-Ladipo… - Molecules, 2024 - mdpi.com
Agunmu (ground herbal medicine) is a form of West African traditional medicine consisting
of a cocktail of herbs. The goal of this study is to evaluate a formulation of Agunmu made …

Mechanism of antimalarial action and mitigation of infection-mediated mitochondrial dysfunction by phyto-constituents of Andrographis paniculata ((Burm f.) Wall. ex …

JO Olanlokun, AB Owolabi, A Odedeyi… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Andrographis paniculata (AP)((Burm f.) Wall. ex Nees) is a
medicinal plant, documented for its folkloric use in the treatment of malaria. Aim This study …

[HTML][HTML] Hexane fraction of Globimetula braunii induces mitochondria-mediated apoptosis in Plasmodium berghei-infected mice

JO Olanlokun, MT Ekundayo, NA Koorbanally… - Toxicology Reports, 2022 - Elsevier
Background Apoptosis is a common pathology in malaria and most antimalarial drugs
induce apoptosis during chemotherapy. Globimetula braunii is an African mistletoe used for …

Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of Phyllanthus amarus (Schum. and Thonn) in Plasmodium berghei …

JO Olanlokun, CO Babarinde… - Journal of Basic and …, 2021 - degruyter.com
Objectives Broad spectrum antimalarial drugs without deleterious effects on mitochondria
are scarce. It is in this regard that we investigated the potency of methanol extract and …

Antiplasmodial evidence, host mitochondrial biology and possible mechanisms of action of a composite extract of Azadiractha indica and Curcuma longa in …

JO Olanlokun, A Odedeyi, SO Oderinde… - Journal of Parasitic …, 2024 - Springer
Abstract Azadirachta indica A. Juss (Meliaceae)(AI) and Curcuma longa
L.(Zingiberaceae)(CL) are used for malaria treatment but their anti-glycolytic and host …