Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs)
is the neurpathological hallmark of Parkinson's disease (PD) and related synucleinopathies …

Valproic acid (VPA), a branched short‐chain fatty acid, is widely used as an antiepileptic
drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of …

Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in
histones and other proteins and in regulating fundamental cellular activities such as …

The development of antisense oligonucleotide therapy is an important advance in the
identification of corrective therapy for neuromuscular diseases, such as spinal muscular …

Parkinson's disease (PD) is the most common movement disorder affecting more than 4
million people worldwide. The primary motor symptoms of the disease are due to …

Parkinson's disease is the second most common neurodegenerative disease, after
Alzheimer's disease, among the aging human population. The main symptoms of …

Valproic acid (VPA, 2-propylpentanoic acid) has been widely used as an antiepileptic drug
and for the therapy of bipolar disorders for several years. Its mechanism of action was …

We recently demonstrated that protein kinase Cδ (PKCδ), an important member of the novel
PKC family, is a key oxidative stress-sensitive kinase that can be activated by caspase-3 …

Valproic acid (VPA), an established antiepileptic and antimanic drug, has recently emerged
as a promising neuroprotective agent. Among its many cellular targets, VPA has been …

In the central nervous system (CNS), dopamine (DA) is involved in motor and cognitive
functions. Although the cerebellum is not been considered an elective dopaminergic region …