Ocular benzalkonium chloride exposure: problems and solutions

MH Goldstein, FQ Silva, N Blender, T Tran, S Vantipalli - Eye, 2022 - nature.com
Preservatives in multidose formulations of topical ophthalmic medications are crucial for
maintaining sterility but can be toxic to the ocular surface. Benzalkonium chloride (BAK) …

The use of preservatives in dry eye drops

K Walsh, L Jones - Clinical Ophthalmology, 2019 - Taylor & Francis
Topical ocular preparations are widely recommended by health care professionals, or
chosen by patients, to help manage dry eye disease (DED). The chronic and progressive …

Preservatives in glaucoma medication

DW Steven, P Alaghband, KS Lim - British Journal of Ophthalmology, 2018 - bjo.bmj.com
Preservatives continue to be in widespread use in ophthalmic medications due to the
convenience they provide, regulatory requirements and the higher cost of alternatives …

Preservative-free prostaglandin analogs and prostaglandin/timolol fixed combinations in the treatment of glaucoma: efficacy, safety and potential advantages

G Holló, A Katsanos, KG Boboridis, M Irkec… - Drugs, 2018 - Springer
Glaucoma therapy-related ocular surface disease (OSD) is a serious pathology with a broad
spectrum of insidious clinical presentations and complex pathogenesis that undermines …

Glaucoma therapy: preservative-free for all?

J Thygesen - Clinical Ophthalmology, 2018 - Taylor & Francis
Preservatives used in topical glaucoma medications have a plethora of well-described toxic
effects on the ocular surface. Such ocular toxicity is manifest clinically as ocular surface …

Devices and treatments to address low adherence in glaucoma patients: A narrative review

B Cvenkel, M Kolko - Journal of Clinical Medicine, 2022 - mdpi.com
Poor adherence to topical glaucoma medications has been linked to worse visual field
outcomes in glaucoma patients. Therefore, identifying and overcoming the adherence …

Preservatives and ocular surface disease: a review

MY Kahook, CJ Rapuano, EM Messmer, NM Radcliffe… - The ocular …, 2024 - Elsevier
Ocular surface disease (OSD) is a complex condition that can cause a range of symptoms
(eg, dryness, irritation, and pain) and can significantly impact the quality of life of affected …

A narrative review of ocular surface disease related to anti-glaucomatous medications

X Zhou, X Zhang, D Zhou, Y Zhao, X Duan - Ophthalmology and Therapy, 2022 - Springer
Topical anti-glaucomatous medications are still the most important measure to lower
intraocular pressure. Large number of studies have confirmed that long-term use of anti …

Glaucoma and dry eye disease: Opportunity to assess and treat

LM Nijm, J Schweitzer… - Clinical Ophthalmology, 2023 - Taylor & Francis
Dry eye disease (DED) has been found to occur at a higher prevalence in individuals with
glaucoma than in individuals without glaucoma. The relationship between glaucoma and …

Profiling ocular surface responses to preserved and non‐preserved topical glaucoma medications: a 2‐year randomized evaluation study

I Mohammed, B Kulkarni, LA Faraj… - Clinical & …, 2020 - Wiley Online Library
Background Use of topical glaucoma medications has been reported to cause ocular
surface (OS) discomfort and inflammation. This study explores the profile of inflammatory …