The inclusion of certain polymers within solid dispersion or lipid-based formulations can
maintain drug supersaturation after dispersion and/or digestion of the vehicle, leading to …

Though there is an advantage in using the higher solubility amorphous state in cases where
low solubility limits absorption, physical instability poses a significant barrier limiting its use …

Written at a level comprehensible to non-experts, this handbook covers the current state of
encapsulation and controlled released technologies, presenting the fundamental processes …

One of the challenges in drug development today is that many new drug candidates are
poorly water-soluble, and one of the approaches to overcome this problem is to transfer a …

Naproxen, a non-steroidal anti-inflammatory drug (NSAID), is a biopharmaceutics
classification system (BCS) class II drug whose bioavailability is rate-limited by its …

The objective of this study was to prepare a co-amorphous drug/drug combination between
two BCS class II drugs, simvastatin (SVS) and glipizide (GPZ). This pharmacologically …

The present work deals with improving the solubility of vemurafenib, a practically insoluble
drug, by converting it into an amorphous-solid dispersion using a solventcontrolled …

Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility
and oral bioavailability. However, they lack physical and/or chemical stability. One of the …

In the present study the release mechanism of the sparingly water-soluble drug felodipine
(FELO) from particulate solid dispersions in PVP or PEG was investigated. FT-IR data …

This study investigated the presence of specific drug–excipient interactions in amorphous
solid dispersions of lapatinib (LB) and four commonly used pharmaceutical polymers …