[HTML][HTML] Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases

MM Yeh, DE Bosch, SS Daoud - World journal of gastroenterology, 2019 - ncbi.nlm.nih.gov
Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear
receptor superfamily of ligand-dependent transcription factors that is expressed in liver and …

[PDF][PDF] Human milk lipids induce important metabolic and epigenetic changes in Neonates

K Donda, A Maheshwari - Clinics in perinatology, 2022 - Elsevier
Lipids are a major source of energy during the fetal/neonatal period. Most are received from
the mother, either transplacentally during the intrauterine period or via maternal milk after …

Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth

YA You, EJ Kwon, HS Hwang, SJ Choi, SK Choi… - BMC genomics, 2021 - Springer
Background Preterm birth, defined as parturition before 37 completed weeks of gestation, is
associated with an increased risk of neonatal complications and death, as well as poor …

Identification of TAF1, HNF4A, and CALM2 as potential therapeutic target genes for liver fibrosis

D Ji, GF Chen, JC Wang, LH Cao, F Lu… - Journal of Cellular …, 2019 - Wiley Online Library
The molecular mechanism of liver fibrosis caused by hepatitis C virus (HCV) is not clear. The
aim of this study is to understand the molecular mechanism of liver fibrosis induced by HCV …

Prenatal bisphenol A exposure, DNA methylation, and low birth weight: a pilot study in Taiwan

YF Huang, CH Chang, PJ Chen, IH Lin, YA Tsai… - International journal of …, 2021 - mdpi.com
Prenatal exposure to bisphenol A (BPA) may increase the risk of abnormal birth outcomes,
and DNA methylation might mediate these adverse effects. This study aimed to investigate …

The obesogenic environment: Epigenetic modifications in placental melanocortin 4 receptor gene connected to gestational diabetes and smoking

M Franzago, A Porreca, M D'Ardes, M Di Nicola… - Frontiers in …, 2022 - frontiersin.org
Background Maternal metabolic insults as well as Gestational Diabetes Mellitus (GDM)
influence the fetal health and may affect 'offspring's susceptibility to chronic diseases via …

Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment

A Arpon, FI Milagro, A Laja, V Segura… - …, 2018 - Taylor & Francis
Aim: To analyze whether preterm newborns show differences in methylation patterns in
comparison to full-term newborns in white blood cells. Patients & methods …

Association between the DNA methylations of POMC, MC4R, and HNF4A and metabolic profiles in the blood of children aged 7–9 years

EJ Kwon, YA You, B Park, EH Ha, HS Kim, H Park… - BMC pediatrics, 2018 - Springer
Abstract Background Proopiomelanocortin (POMC), melanocortin 4 receptor (MC4R), and
hepatocyte nuclear factor 4 alpha (HNF4A) are closely associated with weight gain and …

MC4R and HNF4α promoter methylation at birth contribute to triglyceride levels in childhood: a prospective cohort study

EJ Kwon, HA Lee, YA You, JY Yoo, H Park, EA Park… - Medicine, 2019 - journals.lww.com
Although the changes in DNA methylation are assumed to be due to the association
between adverse intrauterine conditions and adult metabolic health, evidence from human …

Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation

J Dou, RJ Schmidt, KS Benke, C Newschaffer… - Epigenetics, 2018 - Taylor & Francis
Cord blood DNA methylation is associated with numerous health outcomes and
environmental exposures. Whole cord blood DNA reflects all nucleated blood cell types …