In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …

In recent years, microbioreactor (MBR) systems have evolved towards versatile bioprocess
engineering tools. They provide a unique solution to combine higher experimental …

Advanced fed-batch microbioreactors mitigate scale up risks and more closely mimic
industrial cultivation practices. Recently, high throughput microscale feeding strategies have …

Shaking bioreactors are the most frequently used reactor system for screening and process
optimization on a small scale. Their success can be attributed to their simple and functional …

Taxadien‐5α‐hydroxylase and taxadien‐5α‐ol O‐acetyltransferase catalyze the oxidation of
taxadiene to taxadien‐5α‐ol and subsequent acetylation to taxadien‐5α‐yl‐acetate in the …

An ultra-high-throughput screening system for NADPH-dependent enzymes, such as
stereospecific alcohol dehydrogenases, was established. It is based on the [2Fe–2S] cluster …

Microorganisms are indispensable in the food industry, but wild-type strains hardly meet the
current industrial demands due to several undesirable traits. Therefore, microbial strain …

Background Escherichia coli (E. coli) is the most abundant expression host for recombinant
proteins. The production efficiency is dependent on a multitude of parameters. Therefore …

This review focuses on recent progress in the technology of high throughput (HTP)
cultivation and its increasing application in quality by design (QbD)-driven bioprocess …

Background Molecular oxygen (O 2) is one of the key metabolites of all obligate and
facultative aerobic pro-and eukaryotes. It plays a fundamental role in energy homeostasis …