Introduction: Four isomeric structures of thiadiazole motifs have outstanding
pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is …

Knoevenagel condensation is an entrenched, prevailing, prominent arsenal following
greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by …

A new series of eighteen imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives was efficiently
synthesized and screened for antiproliferative activity against the National Cancer Institute …

Liver fibrosis is a common public health problem. Patients with liver fibrosis are more likely
to develop cirrhosis, or hepatocellular carcinoma (HCC) as a more serious consequence …

Abstract A novel series of 4, 6-disubstituted pyrazolo [3, 4-d] pyrimidines (7–43) bearing
various anilines at C-4 position and thiophenethyl or thiopentane moieties at C-6 position …

A new series of imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives was efficiently synthesized
and screened for their in vitro antiproliferative activity on a panel of pancreatic ductal …

The cyclin-dependent kinases (CDKs) play a crucial role in cell cycle progression and are
validated targets of cancer therapy. Pyrazolopyrimidines are versatile scaffolds, which have …

Background: Cancer is second leading disease after cardiovascular disease. Presently,
Chemotherapy, Radiotherapy and use of chemicals are some treatments available these …

Three series of new imidazole‐fused imidazo [2, 1‐b][1, 3, 4] thiadiazole analogues
(compounds 20 a–g, 21 a–g, and 22 a–g) have been synthesized, and their antibacterial …

Heterobivalent ligands constituted by two different pharmacophores that bind to different
molecular targets or to two distinct sites on the same molecular target could be one of the …