Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport—an update
Q Mao, JD Unadkat - The AAPS journal, 2015 - Springer
The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …
Membrane transporters in drug development
Nature reviews Drug discovery, 2010 - nature.com
Membrane transporters can be major determinants of the pharmacokinetic, safety and
efficacy profiles of drugs. This presents several key questions for drug development …
efficacy profiles of drugs. This presents several key questions for drug development …
HIV infection and coronary heart disease: mechanisms and management
Antiretroviral therapy has largely transformed HIV infection into a chronic disease condition.
As such, physicians and other providers caring for individuals living with HIV infection need …
As such, physicians and other providers caring for individuals living with HIV infection need …
Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake
M Niemi, MK Pasanen, PJ Neuvonen - Pharmacological reviews, 2011 - ASPET
The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …
Drug–drug interaction studies: regulatory guidance and an industry perspective
T Prueksaritanont, X Chu, C Gibson, D Cui, KL Yee… - The AAPS journal, 2013 - Springer
Recently, the US Food and Drug Administration and European Medicines Agency have
issued new guidance for industry on drug interaction studies, which outline comprehensive …
issued new guidance for industry on drug interaction studies, which outline comprehensive …
[HTML][HTML] Cholesterol lowering drugs
KR Feingold - 2016 - europepmc.org
There are currently eight different classes of drugs available for lowering cholesterol levels.
There are currently seven HMG-CoA reductase inhibitors (statins) approved for lowering …
There are currently seven HMG-CoA reductase inhibitors (statins) approved for lowering …
[HTML][HTML] HIV and HAART-associated dyslipidemia
ER Feeney, PWG Mallon - The open cardiovascular medicine …, 2011 - ncbi.nlm.nih.gov
Effective highly active antiretroviral therapy (HAART) for human immunodeficiency virus-1
(HIV) infection has led to marked improvement in life-expectancy for those infected with HIV …
(HIV) infection has led to marked improvement in life-expectancy for those infected with HIV …
Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and …
Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …
activities represent both a clinical problem and a potential economic loss for the …
SLC family transporters
X Liu - Drug transporters in drug disposition, effects and …, 2019 - Springer
Solute carrier (SLC) family transporters utilize an electrochemical potential difference or an
ion gradient generated by primary active transporters for transporting their substrates across …
ion gradient generated by primary active transporters for transporting their substrates across …
Drug–drug interactions between HMG-CoA reductase inhibitors (statins) and antiviral protease inhibitors
B Chauvin, S Drouot, A Barrail-Tran… - Clinical pharmacokinetics, 2013 - Springer
The HMG-CoA reductase inhibitors are a class of drugs also known as statins. These drugs
are effective and widely prescribed for the treatment of hypercholesterolemia and prevention …
are effective and widely prescribed for the treatment of hypercholesterolemia and prevention …