Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic
neurodegenerative diseases characterised by progressive spasticity of the lower limbs. The …

There are numerous forms of cerebellar disorders from sporadic to genetic diseases. The
aim of this chapter is to provide an overview of the advances and emerging techniques …

Muscular control during walking is believed to be simplified by the coactivation of muscles
called muscle synergies. Although significant corticomuscular connectivity during walking …

Previous studies found significant modification in spatiotemporal parameters of backward
walking in healthy older adults, but the age-related changes in the neuromuscular control …

Recent advances in the performance and evaluation of walking in exoskeletons use various
assessments based on kinematic/kinetic measurements. While such variables provide …

Locomotion is a complex behaviour that requires the coordination of multiple body segments
and muscle groups. Here we investigated how the weakness and spasticity in individuals …

Objective Gait impairment is the cardinal motor symptom in hereditary spastic paraplegias
(HSPs) possibly linked to increased fear of falling and reduced quality of life (QoL). Disease …

Locomotor movements are accommodated to various surface conditions by means of
specific locomotor adjustments. This study examined underlying age-related differences in …

Background In hereditary spastic paraplegia type 4 (SPG4), subclinical gait changes might
occur years before patients realize gait disturbances. The prodromal phase of …

Patients affected by neurological pathologies with motor disorders when they are of working
age have to cope with problems related to employability, difficulties in working, and …