Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …

Cancer cells are optimised for growth and survival via an ability to outcompete normal cells
in their microenvironment. Many of these advantageous cellular adaptations are promoted …

Hypoxia is an important contributor to the heterogeneity of the microenvironment of solid
tumors and is a significant environmental stressor that drives adaptations which are …

Aggressive forms of breast cancer, such as Her2+ and triple negative breast cancer (TNBC),
are enriched in breast cancer stem cells (BCSC) and have limited therapeutic options …

Solid tumors, including breast cancer, are characterized by the hypoxic microenvironment,
extracellular acidosis, and chemoresistance. Hypoxia marker, carbonic anhydrase IX (CAIX) …

In their quest for survival and successful growth, cancer cells optimise their cellular
processes to enable them to outcompete normal cells in their microenvironment. In essence …

Tumor hypoxia represents a severe microenvironmental stress that is frequently associated
with acidosis. Cancer cells respond to these stresses with changes in gene expression that …

Simple Summary Strikingly, there are many literature reports confirming that the SLC7A11
gene is closely related to the tumourigenesis, survival, proliferation, metastasis, therapeutic …

Hypoxia and extracellular acidosis are pathophysiological hallmarks of aggressive solid
tumors. Regulation of intracellular pH (pHi) is essential for the maintenance of tumor cell …

Hypoxia is a common phenomenon that occurs in most solid tumors. Regardless of tumor
origin, the evolution of a hypoxia-adapted phenotype is critical for invasive cancer …