Basal cell carcinomas (BCCs) were essentially a molecular'black box'until some 12 years
ago, when identification of a genetic flaw in a rare subset of patients who have a great …

The epidermis is a self-renewing tissue. The balance between proliferation and
differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) …

Background Bmi1 is an integral component of the Polycomb Repressive Complex 1 (PRC1)
and is involved in the pathogenesis of multiple cancers. It also plays a key role in the …

Cancer stem cells have recently been described in several high‐grade neoplasms. It is still
unclear if they also occur in cutaneous malignancies. Cancer stem cells are not identical …

Throughout adult life, the epidermis and the hair follicle undergo a perpetual cycle of growth,
regression and rest. Stem cells in the epidermis not only ensure the maintenance of …

Cholesteatoma is a temporal bone disease characterized by dysfunctions of keratinocytes.
MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA …

Background The molecular mechanisms of the development and progression of bladder
cancer are poorly understood. The objective of this study was to analyze the expression of …

Basal cell carcinoma is the most common human malignancy in populations of European
origin, and Australia has the highest incidence of basal cell carcinoma in the world. Great …

The polycomb group (PcG) genes are epigenetic suppressors of gene expression that play
an important role in development. In this study, we examine the role of Bmi-1 (B-cell-specific …

Cell‐type‐and cell‐state‐specific patterns of covalent modifications on DNA and histone
tails form global epigenetic profiles that enable spatiotemporal regulation of gene …