The role of enriched environment in neural development and repair

Y Han, M Yuan, YS Guo, XY Shen, ZK Gao… - Frontiers in cellular …, 2022 - frontiersin.org
In addition to genetic information, environmental factors play an important role in the
structure and function of nervous system and the occurrence and development of some …

The relative benefits of environmental enrichment on learning and memory are greater when stressed: A meta-analysis of interactions in rodents

EL Macartney, M Lagisz, S Nakagawa - Neuroscience & Biobehavioral …, 2022 - Elsevier
Abstract Environmental enrichment (“EE”) is expected to alleviate the negative effects of
stress on cognitive performance. However, there are complexities associated with …

Neurodevelopmental origins of substance use disorders: Evidence from animal models of early‐life adversity and addiction

SC Levis, TZ Baram, SV Mahler - European Journal of …, 2022 - Wiley Online Library
Addiction is a chronic relapsing disorder with devastating personal, societal, and economic
consequences. In humans, early‐life adversity (ELA) such as trauma, neglect, and resource …

Communal nesting differentially attenuates the impact of pre-weaning social isolation on behavior in male and female rats during adolescence and adulthood

J Bratzu, M Ciscato, A Pisanu, G Talani… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction Early social isolation (ESI) disrupts neurodevelopmental processes, potentially
leading to long-lasting emotional and cognitive changes in adulthood. Communal nesting …

Current understanding of the roles of gut–brain Axis in the cognitive deficits caused by perinatal stress exposure

MR Rubinstein, AL Burgueño, S Quiroga, MR Wald… - Cells, 2023 - mdpi.com
The term 'perinatal environment'refers to the period surrounding birth, which plays a crucial
role in brain development. It has been suggested that dynamic communication between the …

[HTML][HTML] Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress

M Rincón-Cortés - Addiction neuroscience, 2023 - Elsevier
In humans, exposure to early life stress (ELS) is an established risk factor for the
development of substance use disorders (SUDs) during later life. Similarly, rodents exposed …

Long-term environmental enrichment overcomes depression, learning, and memory impairment in elderly CD-1 mice with maternal sleep deprivation exposure

YM Zhang, RM Wei, XY Li, YZ Feng… - Frontiers in Aging …, 2023 - frontiersin.org
Early-life stress disrupts central nervous system development and increases the risk of
neuropsychiatric disorder in offspring based on rodent studies. Maternal sleep deprivation …

The developmental origins of opioid use disorder and its comorbidities

SC Levis, SV Mahler, TZ Baram - Frontiers in Human Neuroscience, 2021 - frontiersin.org
Opioid use disorder (OUD) rarely presents as a unitary psychiatric condition, and the
comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which …

A novel morphine drinking model of opioid dependence in rats

P Berríos-Cárcamo, M Quezada, D Santapau… - International Journal of …, 2022 - mdpi.com
An animal model of voluntary oral morphine consumption would allow for a pre-clinical
evaluation of new treatments aimed at reducing opioid intake in humans. However, the main …

Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence

ME Quintanilla, M Quezada, P Morales… - Translational …, 2022 - nature.com
The present study investigates the possible therapeutic effects of human mesenchymal stem
cell-derived secretome on morphine dependence and relapse. This was studied in a new …