Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …

Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide.
Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk …

Abstract A glaucoma locus, GLC1A, was identified previously on chromosome 1q. A gene
within this locus (encoding the protein myocilin) subsequently was shown to harbor …

Glaucoma is a leading cause of blindness in virtually every country. Development of an
accurate diagnostic test for presymptomatic detection of individuals at risk is an urgent …

Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …

Glaucoma is the major cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), as the most prevalent form of glaucoma, is a complex inherited disorder …

Charcot-Marie-Tooth disease (CMT) with autosomal recessive (AR) inheritance is a
heterogeneous group of inherited motor and sensory neuropathies. In some families from …

Glaucoma can be inherited as a mendelian autosomal-dominant or autosomal-recessive
trait, or as a complex multifactorial trait. Genetic approaches have helped define the …

Genetic factors have long been implicated in the pathophysiology of primary open-angle
glaucoma (POAG). Recently, myocilin, a gene of unknown function, was associated with …