[HTML][HTML] The role of metabolic ecosystem in cancer progression—metabolic plasticity and mTOR hyperactivity in tumor tissues
A Sebestyén, T Dankó, D Sztankovics… - Cancer and Metastasis …, 2021 - Springer
Despite advancements in cancer management, tumor relapse and metastasis are
associated with poor outcomes in many cancers. Over the past decade, oncogene-driven …
associated with poor outcomes in many cancers. Over the past decade, oncogene-driven …
[HTML][HTML] The role of mitochondrial ATP synthase in cancer
The mitochondrial ATP synthase is a multi-subunit enzyme complex located in the inner
mitochondrial membrane which is essential for oxidative phosphorylation under …
mitochondrial membrane which is essential for oxidative phosphorylation under …
[HTML][HTML] Identification and validation of a prognostic signature for prostate cancer based on ferroptosis-related genes
H Liu, L Gao, T Xie, J Li, T Zhai, Y Xu - Frontiers in oncology, 2021 - frontiersin.org
Ferroptosis, an iron-dependent form of selective cell death, is involved in the development of
many cancers. However, ferroptosis related genes (FRGs) in prostate cancer (PCa) are not …
many cancers. However, ferroptosis related genes (FRGs) in prostate cancer (PCa) are not …
[HTML][HTML] Subgroup-independent mapping of renal cell carcinoma—machine learning reveals prognostic mitochondrial gene signature beyond histopathologic …
Background: Renal cell carcinoma (RCC) is divided into three major histopathologic groups—
clear cell (ccRCC), papillary (pRCC) and chromophobe RCC (chRCC). We performed a …
clear cell (ccRCC), papillary (pRCC) and chromophobe RCC (chRCC). We performed a …
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis
H Liu, S Li, X Liu, Y Chen, H Deng - Journal of proteome research, 2018 - ACS Publications
SIRT3 is a NAD+-dependent mitochondrial protein deacetylase implicated in the regulation
of central metabolism and mitochondrial proteostasis. SIRT3 is downregulated in clear cell …
of central metabolism and mitochondrial proteostasis. SIRT3 is downregulated in clear cell …
[HTML][HTML] Identification of reliable reference genes for gene expression studies in mouse models under microplastics stress
J Mu, Y Wang, M Wang, D Zhang, M Liu - Ecotoxicology and Environmental …, 2023 - Elsevier
Abstract Microplastics (MPs) and nanoplastics (NPs) have been deemed to be newly
emerged contaminants interfering with various physiological processes closely related with …
emerged contaminants interfering with various physiological processes closely related with …
Proteomic profiling reveals dysregulated mitochondrial complex subunits responsible for myocardial toxicity induced by SiNPs
X Zhao, H Xu, Y Li, R Ma, Y Qi, M Zhang, C Guo… - Science of The Total …, 2023 - Elsevier
The relationship between environmental exposure to silica nanoparticles (SiNPs) and
adverse cardiac outcomes has received more attention. Our recent work has revealed a size …
adverse cardiac outcomes has received more attention. Our recent work has revealed a size …
[HTML][HTML] A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson's disease
L Su, C Wang, C Zheng, H Wei, X Song - BMC medical genomics, 2018 - Springer
Background Parkinson's disease (PD) is a long-term degenerative disease that is caused by
environmental and genetic factors. The networks of genes and their regulators that control …
environmental and genetic factors. The networks of genes and their regulators that control …
[HTML][HTML] Natural Polysaccharide β-Glucan Protects against Doxorubicin-Induced Cardiotoxicity by Suppressing Oxidative Stress
X Wang, Y Ji, D Jin, J Qi, X Hou, W Zhao, S Zhou… - Nutrients, 2022 - mdpi.com
Doxorubicin (DOXO) can be used to treat a variety of human tumors, but its clinical
application is limited due to severe cardiotoxic side effect. Here, we explore the role of β …
application is limited due to severe cardiotoxic side effect. Here, we explore the role of β …
[HTML][HTML] Claudin-10 overexpression suppresses human clear cell renal cell carcinoma growth and metastasis by regulating ATP5O and causing mitochondrial …
W Yang, K Zhang, Z Zhang, J Zhou, L Li… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Our previous study has proved that down-regulation of CLDN10 (Claudin-10) in ccRCC
(clear cell renal cell carcinoma) was closely related to tumor metastasis and predicted an …
(clear cell renal cell carcinoma) was closely related to tumor metastasis and predicted an …