Despite advancements in cancer management, tumor relapse and metastasis are
associated with poor outcomes in many cancers. Over the past decade, oncogene-driven …

The mitochondrial ATP synthase is a multi-subunit enzyme complex located in the inner
mitochondrial membrane which is essential for oxidative phosphorylation under …

Ferroptosis, an iron-dependent form of selective cell death, is involved in the development of
many cancers. However, ferroptosis related genes (FRGs) in prostate cancer (PCa) are not …

Background: Renal cell carcinoma (RCC) is divided into three major histopathologic groups—
clear cell (ccRCC), papillary (pRCC) and chromophobe RCC (chRCC). We performed a …

SIRT3 is a NAD+-dependent mitochondrial protein deacetylase implicated in the regulation
of central metabolism and mitochondrial proteostasis. SIRT3 is downregulated in clear cell …

Abstract Microplastics (MPs) and nanoplastics (NPs) have been deemed to be newly
emerged contaminants interfering with various physiological processes closely related with …

The relationship between environmental exposure to silica nanoparticles (SiNPs) and
adverse cardiac outcomes has received more attention. Our recent work has revealed a size …

Background Parkinson's disease (PD) is a long-term degenerative disease that is caused by
environmental and genetic factors. The networks of genes and their regulators that control …

Doxorubicin (DOXO) can be used to treat a variety of human tumors, but its clinical
application is limited due to severe cardiotoxic side effect. Here, we explore the role of β …

Our previous study has proved that down-regulation of CLDN10 (Claudin-10) in ccRCC
(clear cell renal cell carcinoma) was closely related to tumor metastasis and predicted an …