Introduction: Midlife hypertension has been consistently linked with increased risk of
cognitive decline and Alzheimer's disease (AD). Observational studies and randomized …

Neurological/neurovascular disorders constitute the leading cause of disability and the
second leading cause of death globally. Major neurological/neurovascular disorders or …

Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by the
production and deposition of β-amyloid protein (Aβ) and hyperphosphorylated tau, leading …

Diabetes mellitus (DM) is the most commonly occurring cause of neuropathy around the
world and is beginning to grow in countries where there is a risk of obesity. DM Type …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
severe cognitive impairment that ultimately leads to death. Endothelin (ET) and its receptors …

Ca2+ is a highly versatile intracellular second messenger in the central nervous system, and
regulates many complicated cellular processes, including excitation, plasticity and …

Amyloid β protein (Aβ)-and human group IIA secretory phospholipase A2 (sPLA2-IIA)-
induced neuronal cell death have been established as in vitro models for Alzheimer's …

In addition to their potent vasoconstriction effects, endothelins (ETs) show multiple actions in
various tissues including the brain. The brain contains high levels of ETs, and their …

Alzheimer's disease is a neurodegenerative disorder associated with abnormal
accumulation of amyloid-β (Aβ) which can release endothelin (ET). The present study was …

Endothelin is a chemical mediator that helps in maintaining balance within the blood‐brain
barrier by regulating the levels of toxicants and molecules which pass through the brain …