Despite advances in the field of male reproductive health, idiopathic male infertility, in which
a man has altered semen characteristics without an identifiable cause and there is no …

Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and
antioxidants has been established as an important factor that can negatively affect the …

The pentose phosphate pathway, one of the main antioxidant cellular defense systems, has
been related for a long time almost exclusively to its role as a provider of reducing power …

Reactive oxygen species and oxidative stress are closely associated with various
pathologies such as neurodegenerative diseases, ageing and male infertility. Hence …

Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

In brief Reactive oxygen species are generated throughout the pre-implantation period and
are necessary for normal embryo formation. However, at pathological levels, they result in …

The mitochondria, present in almost all eukaryotic cells, produce energy but also contribute
to many other essential cellular functions. One of the unique characteristics of the …

It is widely accepted that oxidative stress plays an important role in the pathophysiology of
male infertility and that antioxidants could have a significant role in the treatment of male …

On the one hand, reactive oxygen species (ROS) are mandatory mediators for essential
cellular functions including the function of germ cells (oocytes and spermatozoa) and …

Embryo development relies on the complex interplay of the basic cellular processes
including proliferation, differentiation and apoptotic cell death. Precise regulation of these …