Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …

Pseudomonas aeruginosa is a key pathogen of chronic infections in the lungs of cystic
fibrosis patients and in patients suffering from chronic wounds of diverse etiology. In these …

Bacteria that readily adapt to different natural environments, can also exploit this versatility
upon infection of the host to persist. Pseudomonas aeruginosa, a ubiquitous Gram-negative …

BACKGROUND Diabetic foot ulcers are a common diabetic complication leading to
alarming figures of amputation, disability, and early mortality. The diabetic glucooxidative …

Pseudomonas aeruginosa can cause complicated urinary tract infections, particularly in
people with catheters, which can lead to pyelonephritis. Whilst some subgroups appear …

The Pseudomonas aeruginosa LasB elastase (elastase B, pseudolysin) is the predominant
protease in the P. aeruginosa secretome. It has been shown to hydrolyse a vast array of host …

Biofilm infections are one of the modern medical world's greatest challenges. Probably, all
non‐obligate intracellular bacteria and fungi can establish biofilms. In addition, there are …

There is a clinical need for improved wound treatments that prevent both infection and
excessive inflammation. TCP-25, a thrombin-derived peptide, is antibacterial and scavenges …

Cell-to-cell signaling via small molecules is an essential process to coordinate behavior in
single species within a community, and also across kingdoms. In this review, we discuss the …

There is a clinical need for conceptually new treatments that target the excessive activation
of inflammatory pathways during systemic infection. Thrombin-derived C-terminal peptides …