The therapeutic journey of benzimidazoles: A review
Y Bansal, O Silakari - Bioorganic & medicinal chemistry, 2012 - Elsevier
Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as
antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton …
antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton …
Structure–activity relationship analysis of benzimidazoles as emerging anti-inflammatory agents: An overview
A significant number of the anti-inflammatory drugs currently in use are becoming obsolete.
These are exceptionally hazardous for long-term use because of their possible unfavourable …
These are exceptionally hazardous for long-term use because of their possible unfavourable …
CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model
M Krauthausen, MP Kummer… - The Journal of …, 2015 - Am Soc Clin Investig
Chemokines are important modulators of neuroinflammation and neurodegeneration. In the
brains of Alzheimer's disease (AD) patients and in AD animal models, the chemokine …
brains of Alzheimer's disease (AD) patients and in AD animal models, the chemokine …
Benzimidazole: A promising pharmacophore
K Shah, S Chhabra, SK Shrivastava… - Medicinal Chemistry …, 2013 - Springer
The aim of this review is to provide an overview on diverse pharmacological activities of the
benzimidazole moiety. This review highlights recent reports of antimicrobial, anticancer …
benzimidazole moiety. This review highlights recent reports of antimicrobial, anticancer …
Design and synthesis of benzimidazole-chalcone derivatives as potential anticancer agents
Numerous reports have shown that conjugated benzimidazole derivatives possess various
kinds of biological activities, including anticancer properties. In this report, we designed and …
kinds of biological activities, including anticancer properties. In this report, we designed and …
A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment
L Dillemans, L De Somer, B Neerinckx… - Cellular and Molecular …, 2023 - Springer
Chemokines are pivotal players in instigation and perpetuation of synovitis through
leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous …
leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous …
[PDF][PDF] A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection
CH Jenh, MA Cox, L Cui, EP Reich, L Sullivan… - BMC immunology, 2012 - Springer
Background The CXCR3 receptor and its three interferon-inducible ligands (CXCL9,
CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 …
CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 …
Chemokine receptor antagonists: part 2
Background: The first part of this two-part review discussed approaches to generating
antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and …
antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and …
Small molecule CXCR3 antagonists
SP Andrews, RJ Cox - Journal of Medicinal Chemistry, 2016 - ACS Publications
Chemokines and their receptors are known to play important roles in disease. More than 40
chemokine ligands and 20 chemokine receptors have been identified, but, to date, only two …
chemokine ligands and 20 chemokine receptors have been identified, but, to date, only two …
NF-κB signaling regulates cell-autonomous regulation of CXCL10 in breast cancer 4T1 cells
The chemokine CXCL10 and its receptor CXCR3 play a role in breast cancer metastasis to
bone and osteoclast activation. However, the mechanism of CXCL10/CXCR3-induced …
bone and osteoclast activation. However, the mechanism of CXCL10/CXCR3-induced …