Metastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor …

The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …

Integrins are cell adhesion receptors, which are typically transmembrane glycoproteins that
connect to the extracellular matrix (ECM). The function of integrins regulated by biochemical …

For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …

Integrins mediate cell–matrix and cell–cell interactions and integrate extracellular cues to
the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is …

Cells recognize and respond to their extracellular environment through transmembrane
receptors such as integrins, which physically connect the extracellular matrix to the …

Integrins are a family of cell adhesion receptors that support and modulate a variety of
cellular functions that are required for tumor metastasis. Integrins expressed by tumor cells …

The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …

Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by
NME genes (also called NM23). Given the fact that not all NME-encoded proteins are …

Advances in our understanding of fundamental biological processes can be made by the
analysis of defects manifested in inherited diseases. The genes responsible for these …