Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …

A growing number of environmental pollutants are known to adversely affect the thyroid
hormone system, and major gaps have been identified in the tools available for the …

Synthetic chemicals with endocrine disrupting properties are pervasive in the environment
and are present in the bodies of humans and wildlife. As thyroid hormones (THs) control …

Background: Studies characterizing associations between phenols, phthalates and thyroid
hormones during pregnancy produce inconsistent results. This divergence may be partly …

This review summarises the current state of knowledge regarding the physiology and control
of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and …

Levothyroxine (LT4) is a safe, effective means of hormone replacement therapy for
hypothyroidism. Here, we review the pharmaceutical, pathophysiological and behavioural …

Abstract The US Environmental Protection Agency is evaluating the ecological and
toxicological effects of per-and polyfluorinated chemicals. A number of perfluorinated …

Developmentally neurotoxic chemicals are a diverse set of substances that have the
potential to interfere with the normal development of the nervous system, which, if perturbed …

In support of the Endocrine Disruptor Screening Program (EDSP), the US EPA's Office of
Research and Development (ORD) is developing high-throughput screening (HTS) …