Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of
developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in …

Epigenetic inheritance plays a crucial role in many biological processes, such as gene
expression in early embryo development, imprinting and the silencing of transposons. It has …

To assess the extent of abnormal gene expression in clones, we assessed global gene
expression by microarray analysis on RNA from the placentas and livers of neonatal cloned …

Mammalian cloning using somatic cells has been accomplished successfully in several
species, and its potential basic, clinical and therapeutic applications are being pursued on …

14 develop abnormally is currently unjustified on scientific grounds and should not be used
by policymakers or other groups as an argument to ban all human cloning research. In our …

Approximately 99.9% of vertebrate species reproduce sexually. The exceptional 0.1%
reproduce via asexual or clonal means, which vary wildly and are fascinating in their own …

The birth of “Dolly,” the first mammal cloned from an adult mammary epithelial cell,
abolished the decades-old scientific dogma implying that a terminally differentiated cell …

The identification of genes and deduced pathways from the mature human oocyte can help
us better understand oogenesis, folliculogenesis, fertilization, and embryonic development …

Mitochondrial DNA (mtDNA) exists in a highly genotoxic environment created by exposure to
reactive oxygen species, somewhat deficient DNA repair, and the relatively low fidelity of …

Regenerative medicine and emerging biotechnologies stand to revolutionize the practice of
medicine. Advancements in stem cell biology, including embryonic and postnatal somatic …