Nonviral vectors for gene delivery
MA Mintzer, EE Simanek - Chemical reviews, 2009 - ACS Publications
Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …
Nanotechnology: intelligent design to treat complex disease
P Couvreur, C Vauthier - Pharmaceutical research, 2006 - Springer
The purpose of this expert review is to discuss the impact of nanotechnology in the treatment
of the major health threats including cancer, infections, metabolic diseases, autoimmune …
of the major health threats including cancer, infections, metabolic diseases, autoimmune …
Bioapplications of hyperbranched polymers
Hyperbranched polymers (HBPs), an important subclass of dendritic macromolecules, are
highly branched, three-dimensional globular nanopolymeric architectures. Attractive …
highly branched, three-dimensional globular nanopolymeric architectures. Attractive …
Cationic polymer based gene delivery systems
SC De Smedt, J Demeester, WE Hennink - Pharmaceutical research, 2000 - Springer
Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and
safely carrythe gene into the nucleus of the desired cells. A series of chemically …
safely carrythe gene into the nucleus of the desired cells. A series of chemically …
[HTML][HTML] PDMAEMA based gene delivery materials
Gene transfection is the transfer of genetic material like DNA into cells. Cationic polymers
which form nanocomplexes with DNA, so-called non-viral gene vectors, are a highly …
which form nanocomplexes with DNA, so-called non-viral gene vectors, are a highly …
[HTML][HTML] Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells
S Douka, LE Brandenburg, C Casadidio… - Journal of Controlled …, 2023 - Elsevier
Natural killer (NK) cells participate in the immune system by eliminating cancer and virally
infected cells through germline-encoded surface receptors. Their independence from prior …
infected cells through germline-encoded surface receptors. Their independence from prior …
Structure− activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery
P van de Wetering, EE Moret… - Bioconjugate …, 1999 - ACS Publications
A number of water-soluble cationic carriers was evaluated as transfectant. Almost all studied
cationic methacrylate/methacrylamide polymers were able to condense the structure of …
cationic methacrylate/methacrylamide polymers were able to condense the structure of …
Biodegradable polymers as non-viral carriers for plasmid DNA delivery
J Luten, CF van Nostrum, SC De Smedt… - Journal of Controlled …, 2008 - Elsevier
Gene therapy holds a great promise for the treatment of acquired and inherited diseases
with a genetic origin that are currently incurable. Non-viral gene delivery systems are …
with a genetic origin that are currently incurable. Non-viral gene delivery systems are …
Polymer systems for gene delivery—past, present, and future
SY Wong, JM Pelet, D Putnam - Progress in Polymer Science, 2007 - Elsevier
Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased
cells. However, its widespread clinical use has faltered in the face of several challenges …
cells. However, its widespread clinical use has faltered in the face of several challenges …
Trimethylated chitosans as non-viral gene delivery vectors: cytotoxicity and transfection efficiency
Chitosans are linear polysaccharides of natural origin that show potential as carriers in drug
and gene delivery. Introducing quaternisation on the chitosan backbone renders the …
and gene delivery. Introducing quaternisation on the chitosan backbone renders the …