Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

The purpose of this expert review is to discuss the impact of nanotechnology in the treatment
of the major health threats including cancer, infections, metabolic diseases, autoimmune …

Hyperbranched polymers (HBPs), an important subclass of dendritic macromolecules, are
highly branched, three-dimensional globular nanopolymeric architectures. Attractive …

Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and
safely carrythe gene into the nucleus of the desired cells. A series of chemically …

Gene transfection is the transfer of genetic material like DNA into cells. Cationic polymers
which form nanocomplexes with DNA, so-called non-viral gene vectors, are a highly …

Natural killer (NK) cells participate in the immune system by eliminating cancer and virally
infected cells through germline-encoded surface receptors. Their independence from prior …

A number of water-soluble cationic carriers was evaluated as transfectant. Almost all studied
cationic methacrylate/methacrylamide polymers were able to condense the structure of …

Gene therapy holds a great promise for the treatment of acquired and inherited diseases
with a genetic origin that are currently incurable. Non-viral gene delivery systems are …

Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased
cells. However, its widespread clinical use has faltered in the face of several challenges …

Chitosans are linear polysaccharides of natural origin that show potential as carriers in drug
and gene delivery. Introducing quaternisation on the chitosan backbone renders the …