Current therapies for multiple sclerosis (MS) reduce both relapses and relapse-associated
worsening of disability, which is assumed to be mainly associated with transient infiltration of …

Bruton's tyrosine kinase (BTK) is an essential component of multiple signaling pathways that
regulate B cell and myeloid cell proliferation, survival, and functions, making it a promising …

The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and
survival of B-lineage cells and, hence, represents a suitable drug target. The number of BTK …

Aberrant activation of Bruton's tyrosine kinase (BTK) plays an important role in pathogenesis
of B-cell lymphomas, suggesting that inhibition of BTK is useful in the treatment of …

Bruton's tyrosine kinase (BTK) is crucial for FcεRI-mediated mast cell activation and
essential for autoantibody production by B cells in chronic spontaneous urticaria (CSU) …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

B-cell receptor (BCR) signaling is a critical pathway in the pathogenesis of several B-cell
malignancies, including chronic lymphocytic leukemia (CLL), and can be targeted by …

Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase
important in B‐lymphocyte development, differentiation, and signaling. Btk is a member of …

Bruton tyrosine kinase (BTK) is a critical effector molecule for B cell development and plays
a major role in lymphoma genesis. Ibrutinib is the first-generation BTK inhibitor. Ibrutinib has …

Mutations in the Bruton's tyrosine kinase (Btk) gene have been linked to severe early B cell
developmental blocks in human X-linked agammaglobulinemia (XLA), and to milder B cell …