Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or
reclining posture. Evidence relevant to understanding the physiology of SB can be derived …

Sedentary behaviour—put simply, too much sitting, as a distinct concept from too little
exercise—is a novel determinant of cardiovascular risk. This definition provides a …

Physical inactivity is the fourth leading global cause of death and is a major contributor to
metabolic and endocrine diseases. In this review we provide a current update of the past 5 …

Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which
may be independent of physical activity. To date, the mechanism (s) that mediate this …

Background Exposure to acute prolonged sitting can result in vascular dysfunction,
particularly within the legs. This vascular dysfunction, assessed using flow-mediated dilation …

1038 Hypertension November 2018 of developing countries, sedentary behaviors have
become the primary default behavioral option, inextricably embedded in work, school …

Decreased cerebrovascular blood flow and function are associated with lower cognitive
functioning and increased risk of neurodegenerative diseases. Prolonged sitting impairs …

The introduction of duplex Doppler ultrasound almost half a century ago signified a
revolutionary advance in the ability to assess limb blood flow in humans. It is now widely …

Prolonged sitting impairs endothelial function in the leg vasculature, and this impairment is
thought to be largely mediated by a sustained reduction in blood flow-induced shear stress …

New evidence suggests that reductions in sedentary behavior may increase physical activity
and improve health. These findings point to new behavioral targets for intervention and new …