Rethinking organoid technology through bioengineering
In recent years considerable progress has been made in the development of faithful
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …
Bioengineering approaches for the advanced organoid research
Recent advances in 3D cell culture technology have enabled scientists to generate stem cell
derived organoids that recapitulate the structural and functional characteristics of native …
derived organoids that recapitulate the structural and functional characteristics of native …
Transfer learning enables predictions in network biology
Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …
connections between genes, which impedes discoveries in settings with limited data …
[HTML][HTML] SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation
Directed differentiation of human pluripotent stem cells to kidney organoids brings the
prospect of drug screening, disease modelling and the generation of tissue for renal …
prospect of drug screening, disease modelling and the generation of tissue for renal …
Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues
The generation of organoids and tissues with programmable cellular complexity,
architecture and function would benefit from the simultaneous differentiation of human …
architecture and function would benefit from the simultaneous differentiation of human …
Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites
INTRODUCTION Vertebrate development comprises multiple complex morphogenetic
processes that shape the embryonic body plan through self-organization of pluripotent stem …
processes that shape the embryonic body plan through self-organization of pluripotent stem …
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation
Accumulating evidence demonstrates important roles for metabolism in cell fate
determination. However, it is a challenge to assess metabolism at a spatial resolution that …
determination. However, it is a challenge to assess metabolism at a spatial resolution that …
Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network
Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
Applications of organoids for cancer biology and precision medicine
YH Lo, K Karlsson, CJ Kuo - Nature Cancer, 2020 - nature.com
Organoid technologies enable the creation of in vitro physiologic systems that model tissues
of origin more accurately than classical culture approaches. Seminal characteristics of these …
of origin more accurately than classical culture approaches. Seminal characteristics of these …