We have come a long way in the last years of developing analytical strategies in
metabolomics. We have seen huge progress in tackling multiplatform measurement, data …

Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …

Abstract The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate
dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation …

Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …

The rate of cell growth is crucial for bacterial fitness and drives the allocation of bacterial
resources, affecting, for example, the expression levels of proteins dedicated to metabolism …

It is presently unclear how much individual community members contribute to the overall
metabolic output of a gut microbiota. To address this question, we used the honey bee …

Metabolites, the chemical entities that are transformed during metabolism, provide a
functional readout of cellular biochemistry. With emerging technologies in mass …

Metabolism has been shown to integrate with epigenetics and transcription to modulate cell
fate and function,,. Beyond meeting the bioenergetic and biosynthetic demands of T-cell …

Data analysis is a very challenging task in LC-MS metabolomic studies. The use of powerful
analytical techniques (eg, high-resolution mass spectrometry) provides high-dimensional …

Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid
cell growth and proliferation,. RNA interference (RNAi)-based loss-of-function screening has …