[HTML][HTML] 5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition

C Sethy, CN Kundu - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the
knowledge of its mechanism of action, various treatment modalities have been developed …

Ferroptosis-driven nanotherapeutics for cancer treatment

X Shan, S Li, B Sun, Q Chen, J Sun, Z He… - Journal of Controlled …, 2020 - Elsevier
The clinical efficacy of existing cancer therapies is still far from satisfactory. There is an
urgent need to integrate the emerging biomedical discovery and technological innovation …

Nanoparticles in cancer diagnosis and treatment

J Baranwal, B Barse, A Di Petrillo, G Gatto, L Pilia… - Materials, 2023 - mdpi.com
The use of tailored medication delivery in cancer treatment has the potential to increase
efficacy while decreasing unfavourable side effects. For researchers looking to improve …

[HTML][HTML] Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review

A Doustmihan, M Fathi, MA Mazloomi, A Salemi… - Journal of Controlled …, 2023 - Elsevier
There is increasing evidence that malignant tumors are initiated and maintained by a sub-
population of tumor cells that have similar biological properties to normal adult stem cells …

[HTML][HTML] Ferroptosis in colorectal cancer: Potential mechanisms and effective therapeutic targets

Y Wang, Z Zhang, W Sun, J Zhang, Q Xu, X Zhou… - Biomedicine & …, 2022 - Elsevier
Colorectal cancer (CRC) is a common malignant tumor characterized by unchecked division
and survival of abnormal cells in the colon or rectum with high morbidity and mortality …

Nanoparticles for targeted drug delivery to cancer stem cells: a review of recent advances

YN Ertas, K Abedi Dorcheh, A Akbari, E Jabbari - Nanomaterials, 2021 - mdpi.com
Cancer stem cells (CSCs) are a subpopulation of cells that can initiate, self-renew, and
sustain tumor growth. CSCs are responsible for tumor metastasis, recurrence, and drug …

Tumour microenvironment stress promotes the development of drug resistance

NA Seebacher, M Krchniakova, AE Stacy, J Skoda… - Antioxidants, 2021 - mdpi.com
Multi-drug resistance (MDR) is a leading cause of cancer-related death, and it continues to
be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to …

Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies

R Khademi, Z Mohammadi, R Khademi… - Nanoscale …, 2023 - pubs.rsc.org
Background: Leukemia is a malignant disease that threatens human health and life. Nano-
delivery systems improve drug solubility, bioavailability, and blood circulation time, and …

Recent progress on nanomedicine-induced ferroptosis for cancer therapy

H Zafar, F Raza, S Ma, Y Wei, J Zhang, Q Shen - Biomaterials Science, 2021 - pubs.rsc.org
The current treatment strategies for cancer therapy have posed many problems in achieving
high efficacy. Therefore, an urgent step is needed to develop innovative therapies that can …

Ferroptosis-inducing nanomedicine for cancer therapy

Y Wang, T Liu, X Li, H Sheng, X Ma… - Frontiers in Pharmacology, 2021 - frontiersin.org
Ferroptosis, a new iron-and reactive oxygen species–dependent form of regulated cell
death, has attracted much attention in the therapy of various types of tumors. With the …