Zika virus (ZIKV) is an emerging virus from the Flaviviridae family that is transmitted to
humans by mosquito vectors and represents an important health problem. Infections in …

The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …

Influenza A virus (IAV) polymerase protein PB2 has been shown to partially inhibit the host
immune response by blocking the induction of interferons (IFNs). However, the IAV PB2 …

The global spread of SARS-CoV-2 led to major economic and health challenges worldwide.
Revealing host genes essential for infection by multiple variants of SARS-CoV-2 can provide …

Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not
contain viral genetic materials. They are safe and effective immune stimulators and play …

The ubiquitin system denotes a potent post-translational modification machinery that is
capable of activation or deactivation of target proteins through reversible linkage of a single …

The tripartite motif (TRIM) protein family is the largest subfamily of E3 ubiquitin ligases,
playing a crucial role in the antiviral process. In this study, we found that TRIM72, a member …

The Ubiquitin proteasome system (UPS), an essential eukaryotic/host/cellular post-
translational modification (PTM), plays a critical role in the regulation of diverse cellular …

Mosquito-borne flaviviruses such as dengue (DENV) and Zika (ZIKV) cause hundreds of
millions of infections annually. The single-stranded RNA genome of flaviviruses is translated …

Current epidemics, such as AIDS or flu, and the emergence of new threatening pathogens,
such as the one causing the current coronavirus disease 2019 (COVID-19) pandemic …