Protein kinetic stability
JM Sanchez-Ruiz - Biophysical chemistry, 2010 - Elsevier
The relevance of protein stability for biological function and molecular evolution is widely
recognized. Protein stability, however, comes in two flavours: thermodynamic stability, which …
recognized. Protein stability, however, comes in two flavours: thermodynamic stability, which …
When fast is better: protein folding fundamentals and mechanisms from ultrafast approaches
V Munoz, M Cerminara - Biochemical Journal, 2016 - portlandpress.com
Protein folding research stalled for decades because conventional experiments indicated
that proteins fold slowly and in single strokes, whereas theory predicted a complex interplay …
that proteins fold slowly and in single strokes, whereas theory predicted a complex interplay …
Unfolded protein and peptide dynamics investigated with single-molecule FRET and correlation spectroscopy from picoseconds to seconds
Single-molecule fluorescence spectroscopy and correlation methods are finding increasing
applications in the investigation of biomolecular dynamics, especially together with Förster …
applications in the investigation of biomolecular dynamics, especially together with Förster …
Modern semiempirical electronic structure methods and machine learning potentials for drug discovery: Conformers, tautomers, and protonation states
Modern semiempirical electronic structure methods have considerable promise in drug
discovery as universal “force fields” that can reliably model biological and drug-like …
discovery as universal “force fields” that can reliably model biological and drug-like …
Chemical, physical, and theoretical kinetics of an ultrafast folding protein
An extensive set of equilibrium and kinetic data is presented and analyzed for an ultrafast
folding protein—the villin subdomain. The equilibrium data consist of the excess heat …
folding protein—the villin subdomain. The equilibrium data consist of the excess heat …
Reconfiguring self-assembly of photoresponsive hybrid colloids
N Kang, J Zhu, X Zhang, H Wang… - Journal of the American …, 2022 - ACS Publications
The reconfigurable self-assembly of colloidal particles allows the bottom-up creation of
adaptive materials, yet significant challenges remain. Here, we demonstrate a synthesis of …
adaptive materials, yet significant challenges remain. Here, we demonstrate a synthesis of …
Insights into protein folding mechanisms from large scale analysis of mutational effects
AN Naganathan, V Muñoz - Proceedings of the National …, 2010 - National Acad Sciences
Protein folding mechanisms are probed experimentally using single-point mutant
perturbations. The relative effects on the folding (ϕ-values) and unfolding (1-ϕ) rates are …
perturbations. The relative effects on the folding (ϕ-values) and unfolding (1-ϕ) rates are …
Evaluating β-turn mimics as β-sheet folding nucleators
β-Turns are common conformations that enable proteins to adopt globular structures, and
their formation is often rate limiting for folding. β-Turn mimics, molecules that replace the i+ 1 …
their formation is often rate limiting for folding. β-Turn mimics, molecules that replace the i+ 1 …
Modern analysis of protein folding by differential scanning calorimetry
B Ibarra-Molero, AN Naganathan… - Methods in …, 2016 - Elsevier
Differential scanning calorimetry (DSC) is a very powerful tool for investigating protein
folding and stability because its experimental output reflects the energetics of all …
folding and stability because its experimental output reflects the energetics of all …
Secondary structure in nonpeptidic supramolecular block copolymers
Conspectus Proteins contain a level of complexity—secondary and tertiary structures—that
polymer chemists aim to imitate. The bottom-up synthesis of protein-mimicking polymers …
polymer chemists aim to imitate. The bottom-up synthesis of protein-mimicking polymers …