Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation
Methicillin-resistant Staphylococcus aureus (MRSA) is becoming lethal to humanity due to
easy transmission and difficult-to-treat skin and flimsy diseases. The most threatening aspect …
easy transmission and difficult-to-treat skin and flimsy diseases. The most threatening aspect …
Antibacterial pyrazoles: Tackling resistant bacteria
MA Alam - Future Medicinal Chemistry, 2022 - Taylor & Francis
Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine,
food production and ultimately life expectancy. Antibiotic resistance is a global concern …
food production and ultimately life expectancy. Antibiotic resistance is a global concern …
Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus
Vancomycin-resistant enterococci (VRE) are the second leading cause of hospital-acquired
infections (HAIs) attributed to a drug-resistant bacterium in the United States, and resistance …
infections (HAIs) attributed to a drug-resistant bacterium in the United States, and resistance …
Development and antibacterial properties of 4-[4-(anilinomethyl)-3-phenylpyrazol-1-yl] benzoic acid derivatives as fatty acid biosynthesis inhibitors
A number of novel pyrazole derivatives have been synthesized, and several of these
compounds are potent antibacterial agents with minimum inhibitory concentrations as low as …
compounds are potent antibacterial agents with minimum inhibitory concentrations as low as …
Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability
SK Ihmaid, SY Alraqa, MR Aouad, A Aljuhani… - Bioorganic …, 2021 - Elsevier
This study reports an efficient and convenient click chemistry synthesis of a novel series of
phthalimide scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments …
phthalimide scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments …
SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteria
Antibiotic-resistant bacteria represent a serious threat to modern medicine and human life.
Only a minority of antibacterial agents are active against Gram-negative bacteria. Hence, the …
Only a minority of antibacterial agents are active against Gram-negative bacteria. Hence, the …
Discovery of Unique Bis-Substituted Aromatic Amide Derivatives as Novel Highly Potent Antibiotics for Combating Methicillin-Resistant Staphylococcus aureus …
W Guo, Z Yang, K Wang, W Li, Y Zhao… - Journal of Medicinal …, 2024 - ACS Publications
Due to the increasing antibiotic resistance, developing novel antimicrobials to fight infections
caused by resistant bacteria is imperative. Herein, a series of novel bis-substituted aromatic …
caused by resistant bacteria is imperative. Herein, a series of novel bis-substituted aromatic …
Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance
RM Hassan, MS Abd El-Maksoud, IAY Ghannam… - European Journal of …, 2023 - Elsevier
The tremendous increase in the bacterial resistance to the available antibiotics is a serious
problem for the treatment of various infections. Biofilm formation in bacteria significantly …
problem for the treatment of various infections. Biofilm formation in bacteria significantly …
Aerogels as promising materials for antibacterial applications: A mini-review
The increasing cases of bacterial infections originating from resistant bacteria are a serious
problem globally and many approaches have been developed for different purposes to treat …
problem globally and many approaches have been developed for different purposes to treat …
Acetic acid mediated for one-pot synthesis of novel pyrazolyl s-triazine derivatives for the targeted therapy of triple-negative breast tumor cells (MDA-MB-231) via …
Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-
pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5, 5-dimethyl …
pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5, 5-dimethyl …