[HTML][HTML] How caffeic acid and its derivatives combat diabetes and its complications: A systematic review

I Akhlaghipour, AN Shad, VR Askari, A Maharati… - Journal of Functional …, 2023 - Elsevier
Caffeic acid (CA) and its derivatives, caffeic acid phenyl ethyl amide (CAPA) and caffeic acid
phenyl ester (CAPE), were shown to have anti-oxidant, anti-inflammatory, and anti-diabetic …

P450 Monooxygenases Enable Rapid Late‐Stage Diversification of Natural Products via C−H Bond Activation

ND Fessner - ChemCatChem, 2019 - Wiley Online Library
The biological potency of natural products has been exploited for decades. Their inherent
structural complexity and natural diversity might hold the key to efficiently address the urgent …

Nitric oxide system and bronchial epithelium: more than a barrier

MA Bayarri, J Milara, C Estornut, J Cortijo - Frontiers in physiology, 2021 - frontiersin.org
Airway epithelium forms a physical barrier that protects the lung from the entrance of inhaled
allergens, irritants, or microorganisms. This epithelial structure is maintained by tight …

Occurrence, synthesis and biological activity of 2-(2-phenyethyl) chromones

M Fan, W Yang, M He, Y Li, Z Peng, G Wang - European Journal of …, 2022 - Elsevier
(2-Phenylethyl) chromones (PECs) are a group of naturally occurring compounds, which are
characterized as phenylethyl substituent at the C2 position of chromone. They have been …

Effects of rosmarinic acid, carnosic acid, rosmanol, carnosol, and ursolic acid on the pathogenesis of respiratory diseases

F Farhadi, V Baradaran Rahimi, N Mohamadi… - Biofactors, 2023 - Wiley Online Library
This review aimed to identify preclinical and clinical studies examining the effects of
rosmarinic acid (RA), carnosic acid (CaA), rosmanol (RO), carnosol (CA), and ursolic acid …

[HTML][HTML] Auraptene-induced cytotoxicity mechanisms in human malignant glioblastoma (U87) cells: role of reactive oxygen species (ROS)

AR Afshari, M Jalili-Nik, M Soukhtanloo, A Ghorbani… - EXCLI …, 2019 - ncbi.nlm.nih.gov
Glioblastoma multiforme (GBM), like the devastating type of astrocytic tumors, is one of the
most challenging cancers to treat owing to its aggressive nature. Auraptene, as a prenyloxy …

Auto-regulation of secretory flux by sensing and responding to the folded cargo protein load in the endoplasmic reticulum

A Subramanian, A Capalbo, NR Iyengar, R Rizzo… - Cell, 2019 - cell.com
Maintaining the optimal performance of cell processes and organelles is the task of auto-
regulatory systems. Here we describe an auto-regulatory device that helps to maintain …

Low Doses of β-Caryophyllene Reduced Clinical and Paraclinical Parameters of an Autoimmune Animal Model of Multiple Sclerosis: Investigating the Role of CB2 …

VR Askari, V Baradaran Rahimi, R Shafiee-Nick - Brain Sciences, 2023 - mdpi.com
Multiple Sclerosis (MS) is a prevalent inflammatory disease in which the immune system
plays an essential role in the damage, inflammation, and demyelination of central nervous …

PDE-mediated cyclic nucleotide compartmentation in vascular smooth muscle cells: from basic to a clinical perspective

M Lorigo, N Oliveira, E Cairrao - Journal of Cardiovascular Development …, 2021 - mdpi.com
Cardiovascular diseases are important causes of mortality and morbidity worldwide.
Vascular smooth muscle cells (SMCs) are major components of blood vessels and are …

Combination of Imipramine, a sphingomyelinase inhibitor, and β-caryophyllene improve their therapeutic effects on experimental autoimmune encephalomyelitis (EAE …

VR Askari, VB Rahimi, SA Tabatabaee… - International …, 2019 - Elsevier
Multiple Sclerosis (MS) is one of the most common inflammatory diseases with the essential
role of immune system in the demyelination, damage and inflammation of the central …