Developmental processes are regulated by the bone morphogenetic protein (BMP) family of
secreted molecules. BMPs bind to serine/threonine kinase receptors and signal through the …

A cancer cell-centric view has long dominated the field of cancer biology. Research efforts
have focussed on aberrant cancer cell signalling pathways and on changes to cancer cell …

MicroRNAs (miRNAs), which are small noncoding RNA molecules, play important roles in
the post-transcriptional regulation process. The microRNA-21 gene (miR-21) has been …

Bone morphogenetic proteins (BMPs) belong to the TGF-β super family, and are essential
for the regulation of foetal development, tissue differentiation and homeostasis and a …

African Americans (AAs) have higher mortality rate from breast cancer than that of
Caucasian Americans (CAs) even when socioeconomic factors are accounted for. To better …

The transforming growth factor-β (TGF-β) family is known to play critical roles in cancer
progression. While the dual role of TGF-β is well described, the function of bone …

Although bone morphogenetic protein-6 (BMP-6) has been identified as a tumor suppressor
associated with breast cancer differentiation and metastasis, the potential roles of BMP-6 in …

Background Bone morphogenetic protein-6 (BMP-6) is critically involved in many
developmental processes. Recent studies indicate that BMP-6 is closely related to tumor …

Background Invasion and metastasis are two important hallmarks of malignant tumors
caused by complex genetic and epigenetic alterations. The present study investigated the …

[Frontiers in Bioscience 16, 865-897, January 1, 2011] 865 Bone morphogenetic protein and
bone metastasis, implication and thera Page 1 [Frontiers in Bioscience 16, 865-897, January 1 …