A narrative review of the role of transthyretin in health and disease

MA Liz, T Coelho, V Bellotti, MI Fernandez-Arias… - Neurology and …, 2020 - Springer
Transthyretin (TTR) is a tetrameric transport protein highly conserved through vertebrate
evolution and synthesized in the liver, choroid plexus, and retinal pigment epithelium. TTR …

The positive side of the Alzheimer's disease amyloid cross-interactions: the case of the Aβ 1-42 peptide with tau, TTR, CysC, and ApoA1

L Ciccone, C Shi, D Di Lorenzo, AC Van Baelen… - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) represents a progressive amyloidogenic disorder whose
advancement is widely recognized to be connected to amyloid-β peptides and Tau …

Undiscovered roles for transthyretin: from a transporter protein to a new therapeutic target for Alzheimer's disease

T Gião, J Saavedra, E Cotrina, J Quintana… - International journal of …, 2020 - mdpi.com
Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the
choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has …

Transthyretin amyloidogenesis inhibitors: from discovery to current developments

T Yokoyama, M Mizuguchi - Journal of Medicinal Chemistry, 2020 - ACS Publications
Transthyretin (TTR) is a homotetrameric protein in human plasma. The dissociation of the
TTR tetramer and misfolding of the TTR monomer result in the formation of amyloid fibrils …

Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: Analysis of structural data for future drug design

L Ciccone, N Tonali, S Nencetti… - Journal of Enzyme …, 2020 - Taylor & Francis
Natural compounds, such as plant and fruit extracts have shown neuroprotective effect
against neurodegenerative diseases. It has been reported that several natural compounds …

The beneficial role of natural endocrine disruptors: Phytoestrogens in Alzheimer's disease

A Domańska, A Orzechowski… - Oxidative Medicine …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia with a growing incidence
rate primarily among the elderly. It is a neurodegenerative, progressive disorder leading to …

Transthyretin stabilization: an emerging strategy for the treatment of alzheimer's disease?

F Saponaro, JH Kim, G Chiellini - International Journal of Molecular …, 2020 - mdpi.com
Transthyretin (TTR), previously named prealbumin is a plasma protein secreted mainly by
the liver and choroid plexus (CP) that is a carrier for thyroid hormones (THs) and retinol …

Endogenous human proteins interfering with amyloid formation

AL Gharibyan, S Wasana Jayaweera, M Lehmann… - Biomolecules, 2022 - mdpi.com
Amyloid formation is a pathological process associated with a wide range of degenerative
disorders, including Alzheimer's disease, Parkinson's disease, and diabetes mellitus type 2 …

Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative …

EY Cotrina, A Gimeno, J Llop… - Journal of Medicinal …, 2020 - ACS Publications
Transthyretin (TTR) modulates the deposition, processing, and toxicity of Abeta (Aβ)
peptides. We have shown that this effect is enhanced in mice by treatment with small …

Preparation of pumpkin oil-based nanoemulsion as a potential estrogen replacement therapy to alleviate neural-immune interactions in an experimental …

MA El-Bana, SM El-Daly, EA Omara, SM Morsy… - Prostaglandins & Other …, 2023 - Elsevier
As estrogen production decreases during menopause; the brain's metabolism tends to stall
and become less effective. Estrogen most likely protects against neurodegeneration …