Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

Primary cilia act as antenna receivers of environmental signals and enable effective
neuronal or glial responses. Disruption of their function is associated with circuit disorders …

Appropriate axonal growth and connectivity are essential for functional wiring of the brain.
Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations …

The primary cilium projects from the surface of most vertebrate cells, where it senses
extracellular signals to regulate diverse cellular processes during tissue development and …

Primary cilia are vital signaling organelles that extend from most types of cells, including
neurons and glia. These structures are essential for development of many tissues and …

The primary cilium, a microtubule based organelle protruding from the cell surface and
acting as an antenna in multiple signaling pathways, takes center stage in the formation of …

Primary cilia are compartmentalized sensory organelles present on the majority of neurons
in the mammalian brain throughout adulthood. Recent evidence suggests that cilia regulate …

Neuronal primary cilia have recently emerged as important contributors to the central
regulation of energy homeostasis. As non-motile, microtubule-based organelles, primary …

Dysfunction of primary cilia is related to dyshomeostasis, leading to a wide range of
disorders. The ventromedial hypothalamus (VMH) is known to regulate several homeostatic …