The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family
Abstract The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs)
enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that …
enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that …
[HTML][HTML] Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics
J Dubail, SS Apte - Matrix Biology, 2015 - Elsevier
The mammalian ADAMTS superfamily comprises 19 secreted metalloproteinases and 7
ADAMTS-like proteins, each the product of a distinct gene. Thus far, all appear to be relevant …
ADAMTS-like proteins, each the product of a distinct gene. Thus far, all appear to be relevant …
ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels
J Bernier-Latmani, C Mauri, R Marcone… - Nature …, 2022 - nature.com
The small intestinal villus tip is the first point of contact for lumen-derived substances
including nutrients and microbial products. Electron microscopy studies from the early 1970s …
including nutrients and microbial products. Electron microscopy studies from the early 1970s …
Nano-delivery systems for encapsulation of dietary polyphenols: An experimental approach for neurodegenerative diseases and brain tumors
T Squillaro, A Cimini, G Peluso, A Giordano… - Biochemical …, 2018 - Elsevier
Neurodegenerative diseases (NDs) and brain tumors are severe, disabling, and incurable
disorders that represent a critical problem regarding human suffering and the economic …
disorders that represent a critical problem regarding human suffering and the economic …
Unravelling the genetics of inherited retinal dystrophies: Past, present and future
The identification of the genes underlying monogenic diseases has been of interest to
clinicians and scientists for many years. Using inherited retinal dystrophies as an example of …
clinicians and scientists for many years. Using inherited retinal dystrophies as an example of …
Secreted protease ADAMTS18 in development and disease
J Nie, W Zhang - Gene, 2023 - Elsevier
ADAMTS18 was identified in 2002 as a member of the ADAMTS family of 19 secreted Zinc-
dependent metalloproteinases. Prior to 2016, ADAMTS18 was known as a candidate gene …
dependent metalloproteinases. Prior to 2016, ADAMTS18 was known as a candidate gene …
Molecular pathogenesis and management strategies of ectopia lentis
A Chandra, D Charteris - Eye, 2014 - nature.com
Ectopia lentis (EL) is a condition that can either herald underlying systemic conditions, or be
isolated. The recent expansion in the genetics of these conditions has furthered the …
isolated. The recent expansion in the genetics of these conditions has furthered the …
The Syndrome of Microcornea, Myopic Chorioretinal Atrophy, and Telecanthus (MMCAT) Is Caused by Mutations in ADAMTS18
MA Aldahmesh, MJ Alshammari, AO Khan… - Human …, 2013 - Wiley Online Library
One of us recently described an apparently novel ocular syndrome characterized by
microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) in a number of Saudi …
microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) in a number of Saudi …
ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome
BC Holdener, CJ Percival, RC Grady… - Human molecular …, 2019 - academic.oup.com
Peters plus syndrome (MIM# 261540 PTRPLS), characterized by defects in eye
development, prominent forehead, hypertelorism, short stature and brachydactyly, is caused …
development, prominent forehead, hypertelorism, short stature and brachydactyly, is caused …
Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development
D Ataca, M Caikovski, A Piersigilli, A Moulin… - Biology …, 2016 - journals.biologists.com
The ADAMTS family comprises 19 secreted metalloproteinases that cleave extracellular
matrix components and have diverse functions in numerous disease and physiological …
matrix components and have diverse functions in numerous disease and physiological …