Colorectal cancer is the third most common cancer worldwide with a high mortality rate at
the advanced stages. However, colorectal cancer is not a single type of tumor; its …

Importance Primary tumor location is emerging as an important prognostic factor owing to
distinct biological features. However, the side of origin of colon cancer (CC) still does not …

In recent years, the high heterogeneity of colorectal cancer (CRC) has become evident.
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …

Although clinical management of colon cancer generally has not accounted for the primary
tumor site, left-sided and right-sided colon cancers harbor different clinical and biologic …

Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

Background Differences exist between the proximal and distal colon in terms of
developmental origin, exposure to patterning genes, environmental mutagens, and gut flora …

Background: We sought to clarify the prognostic impact of primary tumor location in
metastatic colorectal cancer (mCRC). Methods: We evaluated the association between …

Background Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with
liver metastases developing in 25–30% of those affected. Previous data suggest a survival …

Colorectal cancer (CRC) exhibits differences in incidence, pathogenesis, molecular
pathways and outcome depending on the location of the tumor. This review focuses on the …

Background Right-and left-sided colon cancers (RC, LC) differ with respect to biology,
pathology and epidemiology. Previous data suggest a mortality difference between RC and …