Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …
severe neural injuries, and is one of the leading causes of death and disability worldwide …
Constitutive immune mechanisms: mediators of host defence and immune regulation
The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …
challenges. Immune responses can be evoked through diverse inducible pathways …
Immune response to dengue and Zika
A Elong Ngono, S Shresta - Annual review of immunology, 2018 - annualreviews.org
Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV)
are human pathogens of global significance. In particular, DENV causes the most prevalent …
are human pathogens of global significance. In particular, DENV causes the most prevalent …
West Nile Virus: biology, transmission, and human infection
TM Colpitts, MJ Conway… - Clinical microbiology …, 2012 - Am Soc Microbiol
SUMMARY West Nile Virus was introduced into the Western Hemisphere during the late
summer of 1999 and has been causing significant and sometimes severe human diseases …
summer of 1999 and has been causing significant and sometimes severe human diseases …
IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling
Although the transcription factors IRF-3 and IRF-7 are considered master regulators of type I
interferon (IFN) induction and IFN stimulated gene (ISG) expression, Irf3−/−× Irf7−/− double …
interferon (IFN) induction and IFN stimulated gene (ISG) expression, Irf3−/−× Irf7−/− double …
Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses
H Cho, SC Proll, KJ Szretter, MG Katze, M Gale Jr… - Nature medicine, 2013 - nature.com
Although susceptibility of neurons in the brain to microbial infection is a major determinant of
clinical outcome, little is known about the molecular factors governing this vulnerability. Here …
clinical outcome, little is known about the molecular factors governing this vulnerability. Here …
Revisiting IRF1-mediated antiviral innate immunity
H Zhou, YD Tang, C Zheng - Cytokine & growth factor reviews, 2022 - Elsevier
Many studies have been conducted over the last few decades to understand better the
functions of IRF3 and IRF7 in antiviral immune responses. However, the precise underlying …
functions of IRF3 and IRF7 in antiviral immune responses. However, the precise underlying …
IRF1 is a transcriptional regulator of ZBP1 promoting NLRP3 inflammasome activation and cell death during influenza virus infection
Innate immune sensing of influenza A virus (IAV) induces activation of various immune
effector mechanisms, including the nucleotide and oligomerization domain, leucine-rich …
effector mechanisms, including the nucleotide and oligomerization domain, leucine-rich …
Effects of sodium butyrate treatment on histone modifications and the expression of genes related to epigenetic regulatory mechanisms and immune response in …
Bacteria that inhabit the epithelium of the animals' digestive tract provide the essential
biochemical pathways for fermenting otherwise indigestible dietary fibers, leading to the …
biochemical pathways for fermenting otherwise indigestible dietary fibers, leading to the …
Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis
Flaviviruses such as Zika virus and West Nile virus have the potential to cause severe
neuropathology if they invade the central nervous system. The type I interferon response is …
neuropathology if they invade the central nervous system. The type I interferon response is …