Mechanisms regulating heterogeneity of haemostatic gene expression in endothelial cells

AM Randi, D Jones, C Peghaire… - Journal of Thrombosis and …, 2023 - Elsevier
The haemostatic system involves an array of circulating coagulation factors, which work in
concert with platelets and the vascular endothelium to promote clotting in a space and time …

Organotypic heterogeneity in microvascular endothelial cell responses in sepsis—a molecular treasure trove and pharmacological Gordian knot

A Cleuren, G Molema - Frontiers in Medicine, 2023 - frontiersin.org
In the last decades, it has become evident that endothelial cells (ECs) in the
microvasculature play an important role in the pathophysiology of sepsis-associated multiple …

Reduced Tie2 in Microvascular Endothelial Cells Is Associated with Organ-Specific Adhesion Molecule Expression in Murine Health and Endotoxemia

PJ Zwiers, JPFE Lucas, RM Jongman, M van Meurs… - Cells, 2023 - mdpi.com
Endothelial cells (ECs) in the microvasculature in organs are active participants in the
pathophysiology of sepsis. Tyrosine protein kinase receptor Tie2 (Tek; Tunica interna …

[HTML][HTML] 脓毒症凝血功能紊乱中内皮作用机制及潜在治疗

严京华, 谭利平 - Advances in Clinical Medicine, 2024 - hanspub.org
脓毒症凝血功能的异常, 几乎发生在所有的脓毒症患者的病理生理进程中,
随着持续的内皮损伤与凝血功能的障碍相互促进, 导致脓毒症的持续进展. 越来越多的学者开始 …

Mécanismes inflammatoires induits par les cellules endothéliales dans la maladie veineuse thromboembolique: inflammation et thrombose veineuse

M Najem - 2022 - theses.hal.science
La maladie veineuse thromboembolique (MVTE) représente la troisième cause de mortalité
cardiovasculaire. Au cours de la formation du thrombus veineux, des DAMPs (damage …

[PDF][PDF] Multi-omic profiling of the pulmonary arterial endothelium reveals disturbed cell adhesion and extracellular matrix reorganization in chronic thromboembolic …

XD Manz - Inflammation and endothelium-platelet interaction in …, 2023 - research.vu.nl
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by occlusion of
pulmonary arteries by organized blood clots and occlusive vascular remodeling. Recent …