Spectres of clock evolution: past, present, and yet to come

ML Jabbur, CH Johnson - Frontiers in Physiology, 2022 - frontiersin.org
Circadian clocks are phylogenetically widespread biological oscillators that allow organisms
to entrain to environmental cycles and use their steady-state phase relationship to anticipate …

Adaptive laboratory evolution of microorganisms: Methodology and application for bioproduction

T Hirasawa, T Maeda - Microorganisms, 2022 - mdpi.com
Adaptive laboratory evolution (ALE) is a useful experimental methodology for fundamental
scientific research and industrial applications to create microbial cell factories. By using ALE …

Changing fitness effects of mutations through long-term bacterial evolution

A Couce, A Limdi, M Magnan, SV Owen, CM Herren… - Science, 2024 - science.org
The distribution of fitness effects of new mutations shapes evolution, but it is challenging to
observe how it changes as organisms adapt. Using Escherichia coli lineages spanning …

Long-term experimental evolution decouples size and production costs in Escherichia coli

DJ Marshall, M Malerba, T Lines… - Proceedings of the …, 2022 - National Acad Sciences
Body size covaries with population dynamics across life's domains. Metabolism may impose
fundamental constraints on the coevolution of size and demography, but experimental tests …

Evolutionary scaling of maximum growth rate with organism size

M Lynch, B Trickovic, CP Kempes - Scientific reports, 2022 - nature.com
Data from nearly 1000 species reveal the upper bound to rates of biomass production
achievable by natural selection across the Tree of Life. For heterotrophs, maximum growth …

What programs the size of animal cells?

S Liu, C Tan, M Tyers, A Zetterberg… - Frontiers in Cell and …, 2022 - frontiersin.org
The human body is programmed with definite quantities, magnitudes, and proportions. At the
microscopic level, such definite sizes manifest in individual cells-different cell types are …

In vivo, in vitro and in silico: an open space for the development of microbe‐based applications of synthetic biology

A Danchin - Microbial Biotechnology, 2022 - Wiley Online Library
Living systems are studied using three complementary approaches: living cells, cell‐free
systems and computer‐mediated modelling. Progresses in understanding, allowing …

Case studies in the assessment of microbial fitness: seemingly subtle changes can have major effects on phenotypic outcomes

SB Worthan, RDP McCarthy, MG Behringer - Journal of Molecular …, 2023 - Springer
Following the completion of an adaptive evolution experiment, fitness evaluations are
routinely conducted to assess the magnitude of adaptation. In doing so, proper …

Expanding the upper‐temperature boundary for the microalga Picochlorum sp. (BPE23) by adaptive laboratory evolution

R Barten, T Peeters, S Navalho… - Biotechnology …, 2022 - Wiley Online Library
Closed photobioreactors reach temperatures that reduce microalgal production or even
cause culture collapses. Cooling can maintain the temperature within tolerable boundaries …

'Evolutionary poker': an agent‐based model of interactome emergence and epistasis tested against Lenski's long‐term E. coli experiments

RS Root‐Bernstein, MI Bernstein - The Journal of Physiology, 2024 - Wiley Online Library
A simple agent‐based model is presented that produces results matching the experimental
data found by Lenski's group for≤ 50,000 generations of Escherichia coli bacteria under …