Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Objective Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma
(HCC) is an increasing healthcare burden worldwide. We examined the role of dietary …

Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

Inflammation contributes to the pathogenesis of most acute and chronic liver diseases.
Inflammasomes are multiprotein complexes that can sense danger signals from damaged …

Acute liver failure (ALF) is a fulminant complication of multiple etiologies, characterized by
rapid hepatic destruction, multi-organ failure and mortality. ALF treatment is mainly limited to …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Metabolic syndrome (MetS), today a major global public health problem, is a cluster of
clinical, metabolic, and biochemical abnormalities, such as central adiposity, hypertension …

Inflammation can be either beneficial or detrimental to the liver, depending on multiple
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …