Triclosan: Antimicrobial mechanisms, antibiotics interactions, clinical applications, and human health

P Shrestha, Y Zhang, WJ Chen… - Journal of Environmental …, 2020 - Taylor & Francis
The large-scale applications of Triclosan in industrial and household products have created
many health and environmental concerns. Despite the fears of its drug-resistance and other …

FabI (enoyl acyl carrier protein reductase)-A potential broad spectrum therapeutic target and its inhibitors

P Rana, SM Ghouse, R Akunuri, YV Madhavi… - European journal of …, 2020 - Elsevier
Abstract Development of new anti-bacterial agents acting upon underexploited targets and
thus evading known mechanisms of resistance is the need of the hour. The highly conserved …

Biological treatment of triclosan using a novel strain of Enterobacter cloacae and introducing naphthalene dioxygenase as an effective enzyme

M Ghafouri, F Pourjafar, ZG Nejad… - Journal of Hazardous …, 2023 - Elsevier
In recent years, triclosan (TCS) has been widely used as an antibacterial agent in personal
care products due to the spread of the Coronavirus. TSC is an emerging contaminant, and …

Computational insights and in vitro validation of antibacterial potential of shikimate pathway-derived phenolic acids as NorA efflux pump inhibitors

K Singh, RM Coopoosamy, NJ Gumede, S Sabiu - Molecules, 2022 - mdpi.com
The expression of the efflux pump systems is the most important mechanism of antibiotic
resistance in bacteria, as it contributes to reduced concentration and the subsequent …

Novel diaryl ether derivatives as InhA inhibitors: Design, synthesis and antimycobacterial activity

OA Abdelaziz, DIA Othman, MM Abdel-Aziz… - Bioorganic …, 2022 - Elsevier
A new series of triclosan (TCL)-mimicking diaryl ether derivatives 7–25 were synthesized
and evaluated as inhibitors of enoyl acyl carrier protein reductase InhA enzyme. In addition …

Acidochromic behavior of dibenzylidene cyclohexanone-based bischalcone: Experimental and theoretical study

MMR Badal, HM Ashekul Islam, M Maniruzzaman… - ACS …, 2020 - ACS Publications
Synthesis and characterization of substituted 2, 6-dibenzylidene cyclohexanone-based
bischalcone derivatives and their optimized geometries were investigated by density …

New InhA Inhibitors Based on Expanded Triclosan and Di-Triclosan Analogues to Develop a New Treatment for Tuberculosis

S Chetty, T Armstrong, S Sharma Kharkwal… - Pharmaceuticals, 2021 - mdpi.com
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR)
tuberculosis (TB) has reinforced the need for the development of new anti-TB drugs. The first …

Synthesis, antifungal activity, 3D-QSAR and controlled release on hydrotalcite study of longifolene-derived diphenyl ether carboxylic acid compounds

X Wu, G Lin, W Duan, B Li, Y Cui, B Cen, F Lei - Molecules, 2023 - mdpi.com
Twenty-two novel longifolene-derived diphenyl ether-carboxylic acid compounds 7a–7v
were synthesized from renewable biomass resources longifolene, and their structures were …

3-Phenoxybenzaldehyde and Glycine-Derived Schiff base M (II) Complexes: Synthesis, molecular Modeling, spectroscopic Exploration, and antimicrobial evaluation

R Sankar, TM Sharmila - Inorganic Chemistry Communications, 2024 - Elsevier
This study synthesized a novel bidentate Schiff base known as 2-((3-phenoxybenzylidene)
amino) acetic acid (HL) derived from glycine and 3-phenoxy benzaldehyde and its M (II) …

Discovery of New Inhibitors of Enoyl-ACP Reductase via Structure-Based Virtual Screening

A Laoud, F Alirachedi, F Ferkous - Physical Chemistry Research, 2023 - physchemres.org
A virtual screening protocol, by combining on 3D-QSAR model with molecular docking
procedure and prediction of physico-chemical properties, was applied to find novel inhibitors …