Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype
such as the gene expression profile of a cell that are heritable during somatic cell divisions …

Abstract Glutathione S‑transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene
that plays an important regulatory role in detoxification, anti‑oxidative damage, and the …

Breast cancer (BC) has yielded approximately 2.26 million new cases and has caused
nearly 685,000 deaths worldwide in the last two years, making it the most common …

The epigenetic impact of DNA methylation in chronic myelogenous leukemia (CML) is not
completely understood. To elucidate its role we analyzed 120 patients with CML for …

Epigenetic alterations of the genome such as DNA promoter methylation and chromatin
remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic …

Introduction Ductal carcinoma in situ (DCIS) is a non-invasive lesion of the breast that is
frequently detected by mammography and subsequently removed by surgery. However, it is …

This study was designed to evaluate the changes in promoter CpG islands hypermethylation
during breast cancer progression from pre-invasive lesions [flat epithelial atypia (FEA) …

Simple Summary Genes can be inactivated by specific modifications of DNA bases, most
often by adding a methyl group to the DNA base cytosine if it is followed by guanosine (CG …

Introduction Identification of gene expression-based breast cancer subtypes is considered a
critical means of prognostication. Genetic mutations along with epigenetic alterations …

Most recent investigations into cancer etiology have identified a key role played by
epigenetics. Specifically, aberrant DNA and histone modifications which silence tumor …