UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein

INM Day, RJ Thompson - Progress in neurobiology, 2010 - Elsevier
UCHL1/PGP 9.5 (also known as UCHL1 and PGP 9.5) was first detected as a “brain-specific
protein” over 28 years ago. The protein is highly conserved and localized in neurones and …

The ubiquitin-proteasome system: potential therapeutic targets for Alzheimer's disease and spinal cord injury

B Gong, M Radulovic… - Frontiers in molecular …, 2016 - frontiersin.org
The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in
eukaryotes. Herein, we will review advances in the understanding of the role of several …

Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring

Y Tozuka, M Kumon, E Wada, M Onodera… - Neurochemistry …, 2010 - Elsevier
Maternal obesity may affect the child's long-term development and health, increasing the risk
of diabetes and metabolic syndrome. In addition to the metabolic and endocrine systems …

The functions of UCH-L1 and its relation to neurodegenerative diseases

R Setsuie, K Wada - Neurochemistry international, 2007 - Elsevier
Parkinson's disease (PD) and Alzheimer's disease (AD), the most common
neurodegenerative diseases, are caused by both genetic and environmental factors …

Secretome of mesenchymal progenitors from the umbilical cord acts as modulator of neural/glial proliferation and differentiation

FG Teixeira, MM Carvalho, A Neves-Carvalho… - Stem cell reviews and …, 2015 - Springer
It was recently shown that the conditioned media (CM) of Human Umbilical Cord
Perivascular Cells (HUCPVCs), a mesenchymal progenitor population residing within the …

Serum concentrations of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein after pediatric traumatic brain injury

S Mondello, F Kobeissy, A Vestri, RL Hayes… - Scientific reports, 2016 - nature.com
Objective reliable markers to assess traumatic brain injury (TBI) and predict outcome soon
after injury are a highly needed tool for optimizing management of pediatric TBI. We …

The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma

L Li, Q Tao, H Jin, A Van Hasselt, FF Poon, X Wang… - Clinical Cancer …, 2010 - AACR
Purpose: Nasopharyngeal carcinoma is prevalent in southern China and Southeast Asia,
with distinct geographic and ethnic distribution. One candidate susceptibility locus has been …

Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1

AE Cartier, SN Djakovic, A Salehi… - Journal of …, 2009 - Soc Neuroscience
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is selectively
and abundantly expressed in the brain, and its activity is required for normal synaptic …

Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia

H Liu, N Povysheva, ME Rose, Z Mi… - Proceedings of the …, 2019 - National Acad Sciences
Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique brain-specific deubiquitinating
enzyme. Mutations in and aberrant function of UCHL1 have been linked to many …

The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders.

B Gong, E Leznik - Drug news & perspectives, 2007 - europepmc.org
Impairment of the ubiquitin-proteasome system (UPS) results in the failure to remove and
degrade misfolded proteins and consequently causes the accumulation of misfolded …