Drug delivery technologies have enabled the development of many pharmaceutical
products that improve patient health by enhancing the delivery of a therapeutic to its target …

Here, we review insulin management options and strategies in nonpregnant adult patients
with type 1 diabetes mellitus (T1DM). Most patients with T1DM should follow a regimen of …

Purpose Basal insulins with improved kinetic properties can potentially be produced using
acylation by fatty acids that enable soluble, high-molecular weight complexes to form post …

Abstract Aims Insulin degludec (IDeg) is a new‐generation basal insulin with an ultra‐long
duration of action. We compared the pharmacodynamic (PD) variability of IDeg and insulin …

Executive Summary and Recommendations A diagnosis of diabetes or hyperglycemia
should be confirmed prior to ordering, dispensing, or administering insulin (A). Insulin is the …

Aim Hypoglycaemia and the fear of hypoglycaemia are barriers to achieving
normoglycaemia with insulin. Insulin degludec (IDeg) has an ultra‐long and stable glucose …

Background Intensive basal-bolus insulin therapy has been shown to improve glycaemic
control and reduce the risk of long-term complications that are associated with type 1 …

Objective: This study investigated the efficacy and safety of insulin degludec (IDeg) once
daily (OD), varying injection timing day to day in subjects with type 1 diabetes. Research …

Alterations in glucose metabolism in individuals with diabetes have been considered for
many years, as they appear at first glance, ie, simply as hyperglycemia, and its surrogate …

The aim of the present review is to offer a current perspective about the consequences of
hypoglycemia and its impact on the diabetic disorder due to the increasing incidence of …