The development and in vivo function of T helper 9 cells
The specialized cytokine secretion profiles of T helper (TH) cells are the basis for a focused
and efficient immune response. On the twentieth anniversary of the first descriptions of the …
and efficient immune response. On the twentieth anniversary of the first descriptions of the …
Th9 cells: differentiation and disease
MH Kaplan - Immunological reviews, 2013 - Wiley Online Library
CD 4+ T‐helper cells regulate immunity and inflammation through the acquisition of
potential to secrete specific cytokines. The acquisition of cytokine‐secreting potential, in a …
potential to secrete specific cytokines. The acquisition of cytokine‐secreting potential, in a …
IL-9-producing T cells: potential players in allergy and cancer
P Angkasekwinai, C Dong - Nature Reviews Immunology, 2021 - nature.com
Abstract IL-9-producing CD4+ T cells have been considered to represent a distinct T helper
cell (TH cell) subset owing to their unique developmental programme in vitro, their …
cell (TH cell) subset owing to their unique developmental programme in vitro, their …
Th9 cells, new players in adaptive immunity
Upon antigen-specific stimulation, naïve CD4+ T cells have the potential to differentiate into
various T helper (Th) cell subsets. Earlier models of Th cell differentiation focused on IFN-γ …
various T helper (Th) cell subsets. Earlier models of Th cell differentiation focused on IFN-γ …
Th9 and other IL-9-producing cells in allergic asthma
S Koch, N Sopel, S Finotto - Seminars in immunopathology, 2017 - Springer
Allergic asthma is a worldwide increasing chronic disease of the airways which affects more
than 300 million people. It is associated with increased IgE, mast cell activation, airway …
than 300 million people. It is associated with increased IgE, mast cell activation, airway …
OX40 signaling favors the induction of TH9 cells and airway inflammation
X Xiao, S Balasubramanian, W Liu, X Chu, H Wang… - Nature …, 2012 - nature.com
The mechanisms that regulate the TH9 subset of helper T cells and diseases mediated by
TH9 cells remain poorly defined. Here we found that the costimulatory receptor OX40 was a …
TH9 cells remain poorly defined. Here we found that the costimulatory receptor OX40 was a …
[HTML][HTML] Role and potential of different T helper cell subsets in adoptive cell therapy
D Andreu-Sanz, S Kobold - Cancers, 2023 - mdpi.com
Simple Summary While most cancer immunotherapies have focused on CD8+ T cells as the
main drivers of antitumor immunity, increasing evidence indicates that CD4+ T cells also …
main drivers of antitumor immunity, increasing evidence indicates that CD4+ T cells also …
Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells
T cell stimulation via glucocorticoid-induced tumor necrosis factor receptor (TNFR)-related
protein (GITR) elicits antitumor activity in various tumor models; however, the underlying …
protein (GITR) elicits antitumor activity in various tumor models; however, the underlying …
[HTML][HTML] NF-κB in cancer immunity: friend or foe?
G Lalle, J Twardowski, Y Grinberg-Bleyer - Cells, 2021 - mdpi.com
The emergence of immunotherapies has definitely proven the tight relationship between
malignant and immune cells, its impact on cancer outcome and its therapeutic potential. In …
malignant and immune cells, its impact on cancer outcome and its therapeutic potential. In …
[HTML][HTML] The outstanding antitumor capacity of CD4+ T helper lymphocytes
Over the past decades, tumor-resident immune cells have been extensively studied to
dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because …
dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because …