T-cell-based immunotherapies hold promise for the treatment of many types of cancer, with
three approved products for B-cell malignancies and a large pipeline of treatments in clinical …

B cells have been long studied for their role and function in the humoral immune system.
Apart from generating antibodies and an antibody-mediated memory response against …

Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …

mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to
their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA …

ABSTRACT Introduction: Coronavirus outbreak 2019 (COVID-19) has affected all the
corners of the globe and created chaos to human life. In order to put some control on the …

To gain mechanistic insights into the functions and developmental dynamics of tumor-
infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA …

Identifying factors underlying resistance to immune checkpoint therapy (ICT) is still
challenging. Most cancer patients do not respond to ICT and the availability of the predictive …

The identification of patient-specific tumor antigens is complicated by the low frequency of T
cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables …

Antigen presentation machinery and professional antigen-presenting cells (APCs) are
fundamental for an efficacious immune response against cancers, especially in the context …

Tumor microenvironment (TME) plays a crucial role in the initiation and progression of lung
adenocarcinoma (LUAD); however, there is still a challenge in understanding the dynamic …