Background: Prader-Willi Syndrome (PWS) is a neurodevelopmental genomic imprinting
disorder with lack of expression of genes inherited from the paternal chromosome 15q11 …

Hypothalamic syndrome (HS) is a rare disorder caused by disease-related and/or treatment-
related injury to the hypothalamus, most commonly associated with rare, non-cancerous …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Pediatric obesity is a highly prevalent chronic disease, which has traditionally been treated
with lifestyle therapy alone. Yet for many youth, lifestyle intervention as a monotherapy is …

Prader–Willi syndrome (PWS) is a complex multisystem disorder due to the absent
expression of the paternally active genes in the PWS critical region on chromosome 15 …

This discussion reflects on concepts of obesity in children and adolescents in the early 21st
century. It includes reflections on its history, definition, epidemiology, diagnostic …

The hypothalamus is the centre of neuroendocrine regulation of energy homeostasis and
appetite. Maldevelopment of, or damage to, the key hypothalamic nuclei disrupts the …

The development of hypothalamic obesity (HO) following craniopharyngioma (CP) and other
suprasellar tumors leads to reduced patient quality of life. No treatment algorithms are …

In early childhood, individuals with Prader‐Willi syndrome (PWS) experience excess weight
gain and severe hyperphagia with food compulsivity, which often leads to early onset morbid …

Abstract Background Prader–Willi syndrome (PWS) is a complex neuroendocrine disorder
affecting approximately 1/15,000–1/30,000 people. Unmet medical needs of individuals with …