Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development

H Yu, O Alkhamis, J Canoura, Y Liu… - Angewandte Chemie …, 2021 - Wiley Online Library
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …

Detection and beyond: Challenges and advances in aptamer-based biosensors

H Yoo, H Jo, SS Oh - Materials Advances, 2020 - pubs.rsc.org
Beyond traditional needs of biosensors such as high sensitivity and selectivity for analyte
detection, newly emerging requirements including a real-time detection ability and in-field …

Point-of-care diagnostics: recent developments in a connected age

S Nayak, NR Blumenfeld, T Laksanasopin… - Analytical …, 2017 - ACS Publications
The field of point-of-care (POC) diagnostics offers the tantalizing possibility of providing
rapid diagnostic results in nonlaboratory settings. Here, we review progress in this research …

Trends in miniaturized biosensors for point-of-care testing

D Liu, J Wang, L Wu, Y Huang, Y Zhang, M Zhu… - TrAC Trends in …, 2020 - Elsevier
The popularization of point-of-care (POC) testing is of great importance in healthcare
diagnostics and other fields in the developing world, especially in resource-limited settings …

Electrochemical biosensors in point‐of‐care devices: recent advances and future trends

ETSG da Silva, DEP Souto, JTC Barragan… - …, 2017 - Wiley Online Library
The use of biosensors in point‐of‐care (POC) testing devices has attracted considerable
attention in the past few years, mainly because of their high specificity, portability, and …

Dopamine and melamine binding to gold nanoparticles dominates their aptamer-based label-free colorimetric sensing

X Liu, F He, F Zhang, Z Zhang, Z Huang… - Analytical chemistry, 2020 - ACS Publications
Target-directed aptamer adsorption by gold nanoparticles (AuNPs) has been widely used to
develop label-free colorimetric biosensors. However, the potential interactions between …

Duplexed aptamers: history, design, theory, and application to biosensing

JD Munzar, A Ng, D Juncker - Chemical Society Reviews, 2019 - pubs.rsc.org
Nucleic acid aptamers are single stranded DNA or RNA sequences that specifically bind a
cognate ligand. In addition to their widespread use as stand-alone affinity binding reagents …

Selection and biosensor application of aptamers for small molecules

F Pfeiffer, G Mayer - Frontiers in chemistry, 2016 - frontiersin.org
Small molecules play a major role in the human body and as drugs, toxins, and chemicals.
Tools to detect and quantify them are therefore in high demand. This review will give an …

One-step wet-chemical synthesis of ternary ZnO/CuO/Co 3 O 4 nanoparticles for sensitive and selective melamine sensor development

MM Alam, AM Asiri, MT Uddin, MA Islam… - New Journal of …, 2019 - pubs.rsc.org
Using one-step wet-chemically synthesized ternary ZnO/CuO/Co3O4 nanoparticles (NPs), a
sensitive chemical sensor was developed to detect melamine selectively using an …

Aptamer-based point-of-care diagnostic platforms

A Dhiman, P Kalra, V Bansal, JG Bruno… - Sensors and Actuators B …, 2017 - Elsevier
This review covers a broad range of well-established and novel diagnostic platforms which
are currently being considered for use in commercial point-of care (POC) diagnostics …